1f62
From Proteopedia
(New page: 200px<br /> <applet load="1f62" size="450" color="white" frame="true" align="right" spinBox="true" caption="1f62" /> '''WSTF-PHD'''<br /> ==Overview== The PHD (pl...) |
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'''WSTF-PHD'''<br /> | '''WSTF-PHD'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1F62 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1F62 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F62 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: zn-finger]] | [[Category: zn-finger]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:46:08 2008'' |
Revision as of 13:46, 15 February 2008
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WSTF-PHD
Overview
The PHD (plant homeo domain) is a approximately 50-residue motif found, mainly in proteins involved in eukaryotic transcription regulation. The, characteristic sequence feature is a conserved Cys(4)-HisCys(3) zinc, binding motif. We have determined the solution structure of the PHD motif, from the human Williams-Beuren syndrome transcription factor (WSTF), protein. The domain folds into an interleaved zinc finger which binds two, Zn(2+) in a similar manner to that of the RING and FYVE domains. The, structure reveals a conserved zinc-binding core, together with two, variable loops that are likely candidates for interactions between the, various PHD domains and their specific ligands.
About this Structure
1F62 is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Structure of the PHD zinc finger from human Williams-Beuren syndrome transcription factor., Pascual J, Martinez-Yamout M, Dyson HJ, Wright PE, J Mol Biol. 2000 Dec 15;304(5):723-9. PMID:11124022
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