1fin
From Proteopedia
(New page: 200px<br /> <applet load="1fin" size="450" color="white" frame="true" align="right" spinBox="true" caption="1fin, resolution 2.3Å" /> '''CYCLIN A-CYCLIN-DEPE...) |
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| - | [[Image:1fin. | + | [[Image:1fin.jpg|left|200px]]<br /><applet load="1fin" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1fin" size=" | + | |
caption="1fin, resolution 2.3Å" /> | caption="1fin, resolution 2.3Å" /> | ||
'''CYCLIN A-CYCLIN-DEPENDENT KINASE 2 COMPLEX'''<br /> | '''CYCLIN A-CYCLIN-DEPENDENT KINASE 2 COMPLEX'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1FIN is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ATP as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1FIN is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ATP:'>ATP</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FIN OCA]. |
==Reference== | ==Reference== | ||
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[[Category: phosphorylation]] | [[Category: phosphorylation]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:47:50 2008'' |
Revision as of 13:47, 15 February 2008
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CYCLIN A-CYCLIN-DEPENDENT KINASE 2 COMPLEX
Overview
The crystal structure of the human cyclinA-cyclin-dependent kinase2, (CDK2)-ATP complex has been determined at 2.3 A resolution. CyclinA binds, to one side of CDK2's catalytic cleft, inducing large conformational, changes in its PSTAIRE helix and T-loop. These changes activate the kinase, by realigning active site residues and relieving the steric blockade at, the entrance of the catalytic cleft.
About this Structure
1FIN is a Protein complex structure of sequences from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex., Jeffrey PD, Russo AA, Polyak K, Gibbs E, Hurwitz J, Massague J, Pavletich NP, Nature. 1995 Jul 27;376(6538):313-20. PMID:7630397
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