1fq9
From Proteopedia
(New page: 200px<br /> <applet load="1fq9" size="450" color="white" frame="true" align="right" spinBox="true" caption="1fq9, resolution 3.0Å" /> '''CRYSTAL STRUCTURE OF...) |
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| - | [[Image:1fq9. | + | [[Image:1fq9.jpg|left|200px]]<br /><applet load="1fq9" size="350" color="white" frame="true" align="right" spinBox="true" |
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caption="1fq9, resolution 3.0Å" /> | caption="1fq9, resolution 3.0Å" /> | ||
'''CRYSTAL STRUCTURE OF A TERNARY FGF2-FGFR1-HEPARIN COMPLEX'''<br /> | '''CRYSTAL STRUCTURE OF A TERNARY FGF2-FGFR1-HEPARIN COMPLEX'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1FQ9 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1FQ9 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FQ9 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: i-set subgroup within the immunoglobulin superfamily]] | [[Category: i-set subgroup within the immunoglobulin superfamily]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:48:53 2008'' |
Revision as of 13:48, 15 February 2008
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CRYSTAL STRUCTURE OF A TERNARY FGF2-FGFR1-HEPARIN COMPLEX
Contents |
Overview
The crystal structure of a dimeric 2:2:2 FGF:FGFR:heparin ternary complex, at 3 A resolution has been determined. Within each 1:1 FGF:FGFR complex, heparin makes numerous contacts with both FGF and FGFR, thereby augmenting, FGF-FGFR binding. Heparin also interacts with FGFR in the adjoining 1:1, FGF:FGFR complex to promote FGFR dimerization. The 6-O-sulfate group of, heparin plays a pivotal role in mediating both interactions. The, unexpected stoichiometry of heparin binding in the structure led us to, propose a revised model for FGFR dimerization. Biochemical data in support, of this model are also presented. This model provides a structural basis, for FGFR activation by small molecule heparin analogs and may facilitate, the design of heparin mimetics capable of modulating FGF signaling.
Disease
Known diseases associated with this structure: Atopic dermatitis, susceptibility to OMIM:[135940], Hypophosphatemic rickets, autosomal dominant OMIM:[605380], Ichthyosis vulgaris OMIM:[135940], Jackson-Weiss syndrome OMIM:[136350], Kallmann syndrome 2 OMIM:[136350], Osteomalacia, tumor-induced OMIM:[605380], Pfeiffer syndrome OMIM:[136350], Tumoral calcinosis, hyperphosphatemic, familial OMIM:[605380]
About this Structure
1FQ9 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization., Schlessinger J, Plotnikov AN, Ibrahimi OA, Eliseenkova AV, Yeh BK, Yayon A, Linhardt RJ, Mohammadi M, Mol Cell. 2000 Sep;6(3):743-50. PMID:11030354
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