1fqy
From Proteopedia
(New page: 200px<br /> <applet load="1fqy" size="450" color="white" frame="true" align="right" spinBox="true" caption="1fqy, resolution 3.80Å" /> '''STRUCTURE OF AQUAPO...) |
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caption="1fqy, resolution 3.80Å" /> | caption="1fqy, resolution 3.80Å" /> | ||
'''STRUCTURE OF AQUAPORIN-1 AT 3.8 A RESOLUTION BY ELECTRON CRYSTALLOGRAPHY'''<br /> | '''STRUCTURE OF AQUAPORIN-1 AT 3.8 A RESOLUTION BY ELECTRON CRYSTALLOGRAPHY'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1FQY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1FQY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FQY OCA]. |
==Reference== | ==Reference== | ||
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[[Category: water channel]] | [[Category: water channel]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:49:17 2008'' |
Revision as of 13:49, 15 February 2008
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STRUCTURE OF AQUAPORIN-1 AT 3.8 A RESOLUTION BY ELECTRON CRYSTALLOGRAPHY
Contents |
Overview
Human red cell AQP1 is the first functionally defined member of the, aquaporin family of membrane water channels. Here we describe an atomic, model of AQP1 at 3.8A resolution from electron crystallographic data., Multiple highly conserved amino-acid residues stabilize the novel fold of, AQP1. The aqueous pathway is lined with conserved hydrophobic residues, that permit rapid water transport, whereas the water selectivity is due to, a constriction of the pore diameter to about 3 A over a span of one, residue. The atomic model provides a possible molecular explanation to a, longstanding puzzle in physiology-how membranes can be freely permeable to, water but impermeable to protons.
Disease
Known diseases associated with this structure: Aquaporin-1 deficiency OMIM:[107776], Blood group, Colton OMIM:[107776]
About this Structure
1FQY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structural determinants of water permeation through aquaporin-1., Murata K, Mitsuoka K, Hirai T, Walz T, Agre P, Heymann JB, Engel A, Fujiyoshi Y, Nature. 2000 Oct 5;407(6804):599-605. PMID:11034202
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