This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1fzb
From Proteopedia
(New page: 200px<br /> <applet load="1fzb" size="450" color="white" frame="true" align="right" spinBox="true" caption="1fzb, resolution 2.9Å" /> '''CRYSTAL STRUCTURE OF...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1fzb. | + | [[Image:1fzb.jpg|left|200px]]<br /><applet load="1fzb" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1fzb" size=" | + | |
caption="1fzb, resolution 2.9Å" /> | caption="1fzb, resolution 2.9Å" /> | ||
'''CRYSTAL STRUCTURE OF CROSSLINKED FRAGMENT D'''<br /> | '''CRYSTAL STRUCTURE OF CROSSLINKED FRAGMENT D'''<br /> | ||
| Line 11: | Line 10: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1FZB is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG and CA as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1FZB is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> and <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FZB OCA]. |
==Reference== | ==Reference== | ||
| Line 28: | Line 27: | ||
[[Category: platelet]] | [[Category: platelet]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:50:00 2008'' |
Revision as of 13:50, 15 February 2008
|
CRYSTAL STRUCTURE OF CROSSLINKED FRAGMENT D
Contents |
Overview
In blood coagulation, units of the protein fibrinogen pack together to, form a fibrin clot, but a crystal structure for fibrinogen is needed to, understand how this is achieved. The structure of a core fragment, (fragment D) from human fibrinogen has now been determined to 2.9 A, resolution. The 86K three-chained structure consists of a coiled-coil, region and two homologous globular entitles oriented at approximately 130, degrees to each other. Additionally, the covalently bound dimer of, fragment D, known as 'double-D', was isolated from human fibrin, crystallized in the presence of a Gly-Pro-Arg-Pro-amide peptide ligand, which simulates the donor polymerization site, and its structure solved by, molecular replacement with the model of fragment D.
Disease
Known diseases associated with this structure: Afibrinogenemia, congenital OMIM:[134820], Afibrinogenemia, congenital OMIM:[134830], Amyloidosis, hereditary renal OMIM:[134820], Dysfibrinogenemia, alpha type, causing bleeding diathesis OMIM:[134820], Dysfibrinogenemia, alpha type, causing recurrent thrombosis OMIM:[134820], Dysfibrinogenemia, beta type OMIM:[134830], Dysfibrinogenemia, gamma type OMIM:[134850], Hypofibrinogenemia, gamma type OMIM:[134850], Thrombophilia, dysfibrinogenemic OMIM:[134830], Thrombophilia, dysfibrinogenemic OMIM:[134850]
About this Structure
1FZB is a Protein complex structure of sequences from Homo sapiens with and as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrin., Spraggon G, Everse SJ, Doolittle RF, Nature. 1997 Oct 2;389(6650):455-62. PMID:9333233
Page seeded by OCA on Fri Feb 15 15:50:00 2008
Categories: Homo sapiens | Protein complex | Doolittle, R.F. | Everse, S.J. | Spraggon, G. | CA | NAG | Blood coagulation | Fibrin | Fibrinogen | Plasma | Platelet
