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4ago
From Proteopedia
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| - | + | [[Image:4ago.jpg|left|200px]] | |
| - | The | + | <!-- |
| + | The line below this paragraph, containing "STRUCTURE_4ago", creates the "Structure Box" on the page. | ||
| + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | ||
| + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| + | or leave the SCENE parameter empty for the default display. | ||
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| + | {{STRUCTURE_4ago| PDB=4ago | SCENE= }} | ||
| - | + | ===Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5174=== | |
| - | + | ||
| + | <!-- | ||
| + | The line below this paragraph, {{ABSTRACT_PUBMED_17015838}}, adds the Publication Abstract to the page | ||
| + | (as it appears on PubMed at http://www.pubmed.gov), where 17015838 is the PubMed ID number. | ||
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| + | {{ABSTRACT_PUBMED_17015838}} | ||
| + | |||
| + | ==About this Structure== | ||
| + | [[4ago]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AGO OCA]. | ||
| + | |||
| + | ==Reference== | ||
| + | <ref group="xtra">PMID:017015838</ref><references group="xtra"/> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Boeckler, F M.]] | ||
| + | [[Category: Fersht, A R.]] | ||
| + | [[Category: Joerger, A C.]] | ||
| + | [[Category: Wilcken, R.]] | ||
| + | [[Category: Acetylene linker]] | ||
| + | [[Category: Apoptosis]] | ||
| + | [[Category: Cancer mutation]] | ||
| + | [[Category: Cell cycle]] | ||
| + | [[Category: Halogen bonding]] | ||
| + | [[Category: Protein stabilization]] | ||
| + | [[Category: Small-molecule drug]] | ||
| + | [[Category: Surface crevice]] | ||
| + | [[Category: Transcription]] | ||
| + | [[Category: Zinc binding]] | ||
Revision as of 07:51, 21 March 2012
Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5174
Template:ABSTRACT PUBMED 17015838
About this Structure
4ago is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Joerger AC, Ang HC, Fersht AR. Structural basis for understanding oncogenic p53 mutations and designing rescue drugs. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15056-61. Epub 2006 Oct 2. PMID:17015838
