User:Olivia Cheng/Sandbox 1
From Proteopedia
(Difference between revisions)
(→OspB Fab with H6831) |
|||
| Line 22: | Line 22: | ||
H6831 along with CB2 are a monoclonal antibodies. | H6831 along with CB2 are a monoclonal antibodies. | ||
| - | |||
| - | |||
| - | |||
| - | |||
| - | |||
| - | |||
| - | |||
| - | |||
| - | |||
| - | |||
| - | |||
| - | |||
| - | |||
| - | |||
| - | |||
| - | |||
| - | |||
| - | |||
| - | |||
| - | |||
| - | |||
| - | |||
| - | |||
| - | |||
| - | |||
| - | |||
| - | |||
| - | |||
| - | |||
| - | |||
| - | |||
| - | |||
| - | |||
| - | |||
| - | |||
| - | |||
| - | |||
| - | |||
| - | |||
| - | |||
| - | == Potential Catalytic Triad == | ||
| - | |||
| - | <Structure load='1P4P' size='500' frame='true' align='right' caption='1P4P' scene='Insert optional scene name here' /> | ||
| - | |||
| - | 1P4P | ||
| - | |||
| - | <scene name='User:Olivia_Cheng/Sandbox_1/1p4p_lys253/1'>Lys-253</scene> | ||
| - | |||
| - | |||
| - | There are 3 residues that exist on the eliminated B-sheet of OspB that highly resemble the catalytic triad on Serine proteases. This resemblance of the serine protease catalytic triad consists of <scene name='User:Olivia_Cheng/Sandbox_1/1p4p_activesite/1'>Thr-166, Arg-162, and Glu-184</scene>. | ||
| - | |||
| - | The trio may cause a self-proteolysis. | ||
| - | |||
| - | |||
| - | |||
| - | |||
| - | |||
| - | |||
| - | |||
| - | |||
| - | == References == | ||
| - | |||
| - | Becker, M. Structural Investigation of Borrelia burgodrei OspB, a BactericidalFab Target | ||
| - | |||
| - | Connolly, S. The Versatile Roles of Antibodies in Borrelia Infections | ||
| - | |||
| - | Katona, L. A Bactericidal Monoclonal Antibody Elicits a Change in Its Antigen, OspB of Borrelia burgdorferi, That Can Be Detected by Limited Proteolysis | ||
Revision as of 21:59, 23 March 2012
This is my sandbox!
Lyme disease
OspB Fab with H6831
| |||||||||||
