User:Olivia Cheng/Sandbox 1

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H6831 along with CB2 are a monoclonal antibodies.
H6831 along with CB2 are a monoclonal antibodies.
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== Potential Catalytic Triad ==
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<Structure load='1P4P' size='500' frame='true' align='right' caption='1P4P' scene='Insert optional scene name here' />
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1P4P
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<scene name='User:Olivia_Cheng/Sandbox_1/1p4p_lys253/1'>Lys-253</scene>
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There are 3 residues that exist on the eliminated B-sheet of OspB that highly resemble the catalytic triad on Serine proteases. This resemblance of the serine protease catalytic triad consists of <scene name='User:Olivia_Cheng/Sandbox_1/1p4p_activesite/1'>Thr-166, Arg-162, and Glu-184</scene>.
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The trio may cause a self-proteolysis.
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== References ==
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Becker, M. Structural Investigation of Borrelia burgodrei OspB, a BactericidalFab Target
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Connolly, S. The Versatile Roles of Antibodies in Borrelia Infections
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Katona, L. A Bactericidal Monoclonal Antibody Elicits a Change in Its Antigen, OspB of Borrelia burgdorferi, That Can Be Detected by Limited Proteolysis

Revision as of 22:19, 23 March 2012

This is my sandbox!

Lyme disease


OspB Fab with H6831

1RJL

Drag the structure with the mouse to rotate


OspB consists of .

H6831 along with CB2 are a monoclonal antibodies.





















Potential Catalytic Triad

1P4P

Drag the structure with the mouse to rotate

1P4P


There are 3 residues that exist on the eliminated B-sheet of OspB that highly resemble the catalytic triad on Serine proteases. This resemblance of the serine protease catalytic triad consists of .

The trio may cause a self-proteolysis.





References

Becker, M. Structural Investigation of Borrelia burgodrei OspB, a BactericidalFab Target

Connolly, S. The Versatile Roles of Antibodies in Borrelia Infections

Katona, L. A Bactericidal Monoclonal Antibody Elicits a Change in Its Antigen, OspB of Borrelia burgdorferi, That Can Be Detected by Limited Proteolysis

Proteopedia Page Contributors and Editors (what is this?)

Olivia Cheng

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