User:Susan Corradino
From Proteopedia
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== Introduction == | == Introduction == | ||
| - | Calnexin is an [ http://academic.brooklyn.cuny.edu/biology/bio4fv/page/integra.htm integral protein] found in the plasma membrane of the endoplasmic reticulum. This protein functions as a chaperone protein , forming a super-complex which aids in the formation of the MHC complex. Without calnexin, the MHC complex would be compromised and ultimately be unable to present the peptide required for the immune response. An interesting additional function of the protein is to ensure that misfolded glycoproteins remain in the ER until they are disposed of by the appropriate regulating structures. Calnexin has also been described as a player in aiding in the proper folding of polypeptides | + | Calnexin is an [http://academic.brooklyn.cuny.edu/biology/bio4fv/page/integra.htm integral protein] found in the plasma membrane of the endoplasmic reticulum. This protein functions as a [http://youtu.be/b39698t750c chaperone protein] , forming a super-complex which aids in the formation of the MHC complex. Without calnexin, the MHC complex would be compromised and ultimately be unable to present the peptide required for the immune response. An interesting additional function of the protein is to ensure that misfolded glycoproteins remain in the ER until they are disposed of by the appropriate regulating structures. Calnexin has also been described as a player in aiding in the proper folding of polypeptides |
== 3D Structure == | == 3D Structure == | ||
Revision as of 17:13, 24 March 2012
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- Graduate student
- State University of New York, Old Westbury
- Old Westbury, NY, USA
- Education (Biology). B.S. Marine Vertebrate Biology.
Introduction
Calnexin is an integral protein found in the plasma membrane of the endoplasmic reticulum. This protein functions as a chaperone protein , forming a super-complex which aids in the formation of the MHC complex. Without calnexin, the MHC complex would be compromised and ultimately be unable to present the peptide required for the immune response. An interesting additional function of the protein is to ensure that misfolded glycoproteins remain in the ER until they are disposed of by the appropriate regulating structures. Calnexin has also been described as a player in aiding in the proper folding of polypeptides
