User:Olivia Cheng/Sandbox 1
From Proteopedia
m |
m |
||
| Line 2: | Line 2: | ||
---- | ---- | ||
| + | |||
Lyme disease | Lyme disease | ||
| + | |||
| + | |||
| Line 9: | Line 12: | ||
| - | <Structure load='1RJL' size='500' frame='true' align='right' caption=' | + | <Structure load='1RJL' size='500' frame='true' align='right' caption='[http://proteopedia.com/wiki/index.php/1rjl Model of 1RJL] with Chain C in purple and Chains A, B, and D white' scene='User:Olivia_Cheng/Sandbox_1/1rjl_color/1'/> |
| Line 70: | Line 73: | ||
| - | There are 3 residues that exist on the eliminated B-sheet of OspB that highly resemble the catalytic triad on Serine proteases. For more information on serine | + | There are 3 residues that exist on the eliminated B-sheet of OspB that highly resemble the catalytic triad on Serine proteases. For more information on serine proteaseBecker, M. Structural Investigation of Borrelia burgodrei OspB, a BactericidalFab Targetelf-proteolysis. |
| - | + | ||
| - | + | ||
| Line 83: | Line 84: | ||
== References == | == References == | ||
| - | Becker | + | Becker M, Bunikis J, Lade BD, Dunn JJ, Barbour AG, Lawson CL. Structural investigation of ''Borrelia burgdorferi'' OspB, a bactericidal Fab target. J Biol Chem. 2005 Apr 29;280(17):17363-70. Epub 2005 Feb 15. PMID:15713683 doi:10.1074/jbc.M412842200 |
Connolly, S. The Versatile Roles of Antibodies in Borrelia Infections | Connolly, S. The Versatile Roles of Antibodies in Borrelia Infections | ||
Katona, L. A Bactericidal Monoclonal Antibody Elicits a Change in Its Antigen, OspB of Borrelia burgdorferi, That Can Be Detected by Limited Proteolysis | Katona, L. A Bactericidal Monoclonal Antibody Elicits a Change in Its Antigen, OspB of Borrelia burgdorferi, That Can Be Detected by Limited Proteolysis | ||
Revision as of 04:45, 25 March 2012
This is my sandbox!
Lyme disease
OspB Fab with H6831
|
OspB consists of .
H6831 along with CB2 are a monoclonal antibodies.
Potential Catalytic Triad
|
1P4P
There are 3 residues that exist on the eliminated B-sheet of OspB that highly resemble the catalytic triad on Serine proteases. For more information on serine proteaseBecker, M. Structural Investigation of Borrelia burgodrei OspB, a BactericidalFab Targetelf-proteolysis.
References
Becker M, Bunikis J, Lade BD, Dunn JJ, Barbour AG, Lawson CL. Structural investigation of Borrelia burgdorferi OspB, a bactericidal Fab target. J Biol Chem. 2005 Apr 29;280(17):17363-70. Epub 2005 Feb 15. PMID:15713683 doi:10.1074/jbc.M412842200
Connolly, S. The Versatile Roles of Antibodies in Borrelia Infections
Katona, L. A Bactericidal Monoclonal Antibody Elicits a Change in Its Antigen, OspB of Borrelia burgdorferi, That Can Be Detected by Limited Proteolysis
