User:Olivia Cheng/Sandbox 1
From Proteopedia
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Revision as of 05:36, 25 March 2012
This is my sandbox!
Outer Surface Protein B (OspB) is a component
OspB Interaction with Fab of H6831
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Click here to revert to the .
OspB consists of .
H6831 along with CB2 are a monoclonal antibodies.
Potential Catalytic Triad
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There are 3 residues that exist on the eliminated B-sheet of OspB that highly resemble the catalytic triad on Serine proteases.
References
Becker M, Bunikis J, Lade BD, Dunn JJ, Barbour AG, Lawson CL. Structural investigation of Borrelia burgdorferi OspB, a bactericidal Fab target. J Biol Chem. 2005 Apr 29;280(17):17363-70. Epub 2005 Feb 15. PMID:15713683 doi:10.1074/jbc.M412842200
Connolly, S. The Versatile Roles of Antibodies in Borrelia Infections
Katona, L. A Bactericidal Monoclonal Antibody Elicits a Change in Its Antigen, OspB of Borrelia burgdorferi, That Can Be Detected by Limited Proteolysis
