User:Olivia Cheng/Sandbox 1

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	== OspB Interaction with Fab of H6831 ==		== OspB Interaction with Fab of H6831 ==

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Revision as of 05:56, 25 March 2012

This is my sandbox!

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Outer Surface Protein B (OspB) is a component

Hemoglobin

OspB Interaction with Fab of H6831

spinqualitylabelsall models 1RJL with Chain C in purple and Chains A, B, and D white Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

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OspB consists of .

H6831 along with CB2 are a monoclonal antibodies.

Potential Catalytic Triad

spinqualitylabelsall models 1P4P Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

There are 3 residues that exist on the eliminated B-sheet of OspB that highly resemble the catalytic triad on Serine proteases.

References

Becker M, Bunikis J, Lade BD, Dunn JJ, Barbour AG, Lawson CL. Structural investigation of Borrelia burgdorferi OspB, a bactericidal Fab target. J Biol Chem. 2005 Apr 29;280(17):17363-70. Epub 2005 Feb 15. PMID:15713683 doi:10.1074/jbc.M412842200

Connolly, S. The Versatile Roles of Antibodies in Borrelia Infections

Katona, L. A Bactericidal Monoclonal Antibody Elicits a Change in Its Antigen, OspB of Borrelia burgdorferi, That Can Be Detected by Limited Proteolysis