1g9l
From Proteopedia
(New page: 200px<br /> <applet load="1g9l" size="450" color="white" frame="true" align="right" spinBox="true" caption="1g9l" /> '''SOLUTION STRUCTURE OF THE PABC DOMAIN OF HU...) |
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'''SOLUTION STRUCTURE OF THE PABC DOMAIN OF HUMAN POLY(A) BINDING PROTEIN'''<br /> | '''SOLUTION STRUCTURE OF THE PABC DOMAIN OF HUMAN POLY(A) BINDING PROTEIN'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1G9L is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1G9L is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G9L OCA]. |
==Reference== | ==Reference== | ||
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[[Category: all-helical domain]] | [[Category: all-helical domain]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:51:46 2008'' |
Revision as of 13:51, 15 February 2008
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SOLUTION STRUCTURE OF THE PABC DOMAIN OF HUMAN POLY(A) BINDING PROTEIN
Overview
We have determined the solution structure of the C-terminal quarter of, human poly(A)-binding protein (hPABP). The protein fragment contains a, protein domain, PABC [for poly(A)-binding protein C-terminal domain], which is also found associated with the HECT family of ubiquitin ligases., By using peptides derived from PABP interacting protein (Paip) 1, Paip2, and eRF3, we show that PABC functions as a peptide binding domain. We use, chemical shift perturbation analysis to identify the peptide binding site, in PABC and the major elements involved in peptide recognition. From, comparative sequence analysis of PABC-binding peptides, we formulate a, preliminary PABC consensus sequence and identify human ataxin-2, the, protein responsible for type 2 spinocerebellar ataxia (SCA2), as a, potential PABC ligand.
About this Structure
1G9L is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure and function of the C-terminal PABC domain of human poly(A)-binding protein., Kozlov G, Trempe JF, Khaleghpour K, Kahvejian A, Ekiel I, Gehring K, Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4409-13. Epub 2001 Apr 3. PMID:11287632
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