Mannose-binding protein
From Proteopedia
Michal Harel (Talk | contribs)
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Revision as of 11:32, 26 March 2012
Mannose-binding protein (MBL) is a lectin essential to innate immunity. MBL recognizes carbohydrate patterns like mannose or glucose located on the surface of microorganisms like bacteria]], viruses and fungi. MBL binds to the microorganism and the activation of the lectin pathway ensues. MBL binds to apoptotic and senescent cells and enhances their engulfment by phagocytes. In the blood, MBL is bound to MBL-associated serine protease (MASP-2). Upon binding of MBL to a target mannose, [[the MASP initiates the complement cascade resulting in lysis of the pathogen.
3D structures of mannose-binding protein
1ytt, 1kwt - rMBL fragment]] - rat
1kmb, 1fif - rMBL fragment (mutant)
Mannose-binding protein complex with sugar
1rdi, 1rdj, 1rdk, 1rdl, 1rdm, 1rdn, 1rdo, 1kwu, 1kwv, 1kww, 1kwx – rMBL fragment + monosaccharide
1fih - rMBL fragment (mutant) + monosaccharide
1kwy, 1kx1, 1kza, 1kzd, 1kze - rMBL fragment + bisaccharide
1kwz, 1kx0 - rMBL fragment (mutant) + bisaccharide
1kzb, 1kzc - rMBL fragment + trimannose
