User:Olivia Cheng/Sandbox 1
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| - | --[[User:Olivia Cheng|Olivia Cheng]] 23:30, 27 March 2012 (IST)This is my sandbox! | ||
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| - | Outer Surface Protein B ([[OspB]]) is a component | ||
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| - | [[Hemoglobin]] | ||
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| - | == OspB Interaction with Fab of H6831 == | ||
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| - | <Structure load='1RJL' size='500' frame='true' align='right' caption='[http://proteopedia.com/wiki/index.php/1rjl 1RJL] with Chain C in purple and Chains A, B, and D white' scene='User:Olivia_Cheng/Sandbox_1/1rjl_color/1'/> | ||
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| - | Click here to revert to the <scene name='User:Olivia_Cheng/Sandbox_1/1rjl_color/1'>original model</scene>. | ||
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| - | <scene name='User:Olivia_Cheng/Sandbox_1/1rjl_chainc_transparentabd/2'>Transparent</scene> | ||
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| - | OspB consists of <scene name='User:Olivia_Cheng/Sandbox_1/1rjl_chainc/5'>chain C</scene>. | ||
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| - | <scene name='User:Olivia_Cheng/Sandbox_1/1rjl_chainc_lys253/3'>Lys-253 on Chain C</scene> | ||
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| - | H6831 along with CB2 are a monoclonal antibodies. | ||
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| - | H6831 appears to have a bactericidal effect on OspB in the absence of complement proteins. | ||
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| - | <!--Monoclonal antibodies LINK | ||
| - | [http://www.proteopedia.org/wiki/index.php/Monoclonal_antibody Monoclonal antibodies] | ||
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| - | == Potential Catalytic Triad == | ||
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| - | <!-- | ||
| - | 1P4P link | ||
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| - | <Structure load='1P4P' size='500' frame='true' align='right' caption='[http://proteopedia.com/wiki/index.php/1p4p 1P4P]' scene='' /> | ||
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| - | Proposed Mechanism | ||
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| - | <scene name='User:Olivia_Cheng/Sandbox_1/1p4p_lys253/1'>Lys-253</scene> | ||
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| - | There are 3 residues that exist on the eliminated B-sheet of OspB that highly resemble the catalytic triad on [http://en.wikipedia.org/wiki/Serine_protease Serine proteasoccur. | ||
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| - | == References == | ||
| - | Becker M, Bunikis J, Lade BD, Dunn JJ, Barbour AG, Lawson CL. Structural investigation of ''Borrelia burgdorferi'' OspB, a bactericidal Fab target. J Biol Chem. 2005 Apr 29;280(17):17363-70. Epub 2005 Feb 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15713683 15713683] doi:[http://www.jbc.org/content/280/17/17363 10.1074/jbc.M412842200] | ||
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| - | Connolly, S. The Versatile Roles of Antibodies in Borrelia Infections | ||
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| - | Katona, L. A Bactericidal Monoclonal Antibody Elicits a Change in Its Antigen, OspB of Borrelia burgdorferi, That Can Be Detected by Limited Proteolysis | ||
