1gd5
From Proteopedia
(New page: 200px<br /> <applet load="1gd5" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gd5" /> '''SOLUTION STRUCTURE OF THE PX DOMAIN FROM HU...) |
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'''SOLUTION STRUCTURE OF THE PX DOMAIN FROM HUMAN P47PHOX NADPH OXIDASE'''<br /> | '''SOLUTION STRUCTURE OF THE PX DOMAIN FROM HUMAN P47PHOX NADPH OXIDASE'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1GD5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1GD5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GD5 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: px domain]] | [[Category: px domain]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:52:44 2008'' |
Revision as of 13:52, 15 February 2008
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SOLUTION STRUCTURE OF THE PX DOMAIN FROM HUMAN P47PHOX NADPH OXIDASE
Contents |
Overview
The phox homology (PX) domain is a novel protein module containing a, conserved proline-rich motif. We have shown that the PX domain isolated, from the human p47phox protein, a soluble subunit of phagocyte NADPH, oxidase, binds specifically to the C-terminal SH3 domain derived from the, same protein. The solution structure of p47 PX has an alpha + beta, structure with a novel folding motif topology and reveals that the, proline-rich motif is presented on the molecular surface for easy, recognition by the SH3 domain. The proline-rich motif of p47 PX in the, free state adopts a distorted left-handed polyproline type II helix, conformation.
Disease
Known disease associated with this structure: Chronic granulomatous disease due to deficiency of NCF-1 OMIM:[608512]
About this Structure
1GD5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Solution structure of the PX domain, a target of the SH3 domain., Hiroaki H, Ago T, Ito T, Sumimoto H, Kohda D, Nat Struct Biol. 2001 Jun;8(6):526-30. PMID:11373621
Page seeded by OCA on Fri Feb 15 15:52:44 2008
Categories: Homo sapiens | Single protein | Ago, T. | Hiroaki, H. | Ito, T. | Kohda, D. | Sumimoto, H. | Alpha beta | P47-phox | Px domain
