2c9b
From Proteopedia
(New page: 200px<br /> <applet load="2c9b" size="450" color="white" frame="true" align="right" spinBox="true" caption="2c9b, resolution 2.75Å" /> '''LUMAZINE SYNTHASE F...) |
|||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2C9B is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]] with K, PO4, PUG and MPD as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.9 2.5.1.9]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C9B OCA]]. | + | 2C9B is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]] with K, PO4, PUG and MPD as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Riboflavin_synthase Riboflavin synthase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.9 2.5.1.9]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C9B OCA]]. |
==Reference== | ==Reference== | ||
Structural and thermodynamic insights into the binding mode of five novel inhibitors of lumazine synthase from Mycobacterium tuberculosis., Morgunova E, Illarionov B, Sambaiah T, Haase I, Bacher A, Cushman M, Fischer M, Ladenstein R, FEBS J. 2006 Oct;273(20):4790-804. Epub 2006 Sep 19. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16984393 16984393] | Structural and thermodynamic insights into the binding mode of five novel inhibitors of lumazine synthase from Mycobacterium tuberculosis., Morgunova E, Illarionov B, Sambaiah T, Haase I, Bacher A, Cushman M, Fischer M, Ladenstein R, FEBS J. 2006 Oct;273(20):4790-804. Epub 2006 Sep 19. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16984393 16984393] | ||
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
| + | [[Category: Riboflavin synthase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Bacher, A.]] | [[Category: Bacher, A.]] | ||
| Line 32: | Line 33: | ||
[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:03:50 2007'' |
Revision as of 10:59, 30 October 2007
|
LUMAZINE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS BOUND TO 3-(1,3,7-TRIHYDRO-9-D-RIBITYL-2,6,8-PURINETRIONE-7-YL)
Overview
Recently published genomic investigations of the human pathogen, Mycobacterium tuberculosis have revealed that genes coding the proteins, involved in riboflavin biosynthesis are essential for the growth of the, organism. Because the enzymes involved in cofactor biosynthesis pathways, are not present in humans, they appear to be promising candidates for the, development of therapeutic drugs. The substituted purinetrione compounds, have demonstrated high affinity and specificity to lumazine synthase, which catalyzes the penultimate step of riboflavin biosynthesis in, bacteria and plants. The structure of M. tuberculosis lumazine synthase in, complex with five different inhibitor compounds is presented, together, with studies of the binding reactions by isothermal titration calorimetry., The ... [(full description)]
About this Structure
2C9B is a [Single protein] structure of sequence from [Mycobacterium tuberculosis] with K, PO4, PUG and MPD as [ligands]. Active as [Riboflavin synthase], with EC number [2.5.1.9]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structural and thermodynamic insights into the binding mode of five novel inhibitors of lumazine synthase from Mycobacterium tuberculosis., Morgunova E, Illarionov B, Sambaiah T, Haase I, Bacher A, Cushman M, Fischer M, Ladenstein R, FEBS J. 2006 Oct;273(20):4790-804. Epub 2006 Sep 19. PMID:16984393
Page seeded by OCA on Tue Oct 30 13:03:50 2007
