1gif
From Proteopedia
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'''HUMAN GLYCOSYLATION-INHIBITING FACTOR'''<br /> | '''HUMAN GLYCOSYLATION-INHIBITING FACTOR'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1GIF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1GIF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GIF OCA]. |
==Reference== | ==Reference== | ||
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[[Category: macrophage]] | [[Category: macrophage]] | ||
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Revision as of 13:53, 15 February 2008
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HUMAN GLYCOSYLATION-INHIBITING FACTOR
Contents |
Overview
Glycosylation-inhibiting factor (GIF) is a cytokine that is involved in, the regulation of IgE synthesis. The crystal structure of recombinant, human GIF was determined by the multiple isomorphous replacement method., The structure was refined to an R factor of 0.168 at 1.9 angstrom, resolution. The overall structure is seen to consist of three, interconnected subunits forming a barrel with three 6-stranded beta-sheets, on the inside and six alpha-helices on the outside. There is a, 5-angstrom-diameter "hole" through the middle of the barrel. The barrel, structure of GIF in part resembles other "trefoil" cytokines such as, interleukin 1 and fibroblast growth factor. Each subunit has a new class, of alpha + beta sandwich structure consisting of two beta-alpha-beta, motifs. These beta-alpha-beta motifs are related by a pseudo-twofold axis, and resemble both interleukin 8 and the peptide binding domain of major, histocompatibility complex protein, although the topology of the, polypeptide chain is quite different.
Disease
Known diseases associated with this structure: Persistent Mullerian duct syndrome, type I OMIM:[600957], Rheumatoid arthritis, systemic juvenile, susceptibility to OMIM:[153620]
About this Structure
1GIF is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The crystal structure of human glycosylation-inhibiting factor is a trimeric barrel with three 6-stranded beta-sheets., Kato Y, Muto T, Tomura T, Tsumura H, Watarai H, Mikayama T, Ishizaka K, Kuroki R, Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):3007-10. PMID:8610159
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