1h9v

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(New page: 200px<br /> <applet load="1h9v" size="450" color="white" frame="true" align="right" spinBox="true" caption="1h9v, resolution 3.0&Aring;" /> '''HUMAN FC-GAMMA-RECEP...)
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'''HUMAN FC-GAMMA-RECEPTOR IIA (FCGRIIA), MONOCLINIC'''<br />
'''HUMAN FC-GAMMA-RECEPTOR IIA (FCGRIIA), MONOCLINIC'''<br />
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==About this Structure==
==About this Structure==
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1H9V is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H9V OCA].
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1H9V is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H9V OCA].
==Reference==
==Reference==
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[[Category: immunoglobulin]]
[[Category: immunoglobulin]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 17:14:32 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:55:27 2008''

Revision as of 13:55, 15 February 2008

Image:1h9v.jpg

1h9v, resolution 3.0Å

Drag the structure with the mouse to rotate

HUMAN FC-GAMMA-RECEPTOR IIA (FCGRIIA), MONOCLINIC

Contents

Overview

Once antigen is opsonised by IgG it is removed from the circulation by, Fcgamma-receptor expressing cells. Fcgamma-receptors are type I, transmembrane molecules that carry extracellular parts consisting of two, or three immunoglobulin domains. Previously solved structures of, Fc-receptors reveal that the N-terminal two Ig-like domains are arranged, in a steep angle forming a heart-shaped structure. The crystal structure, of the FcgammaRIII/hIgG1-Fc-fragment demonstrated that the Fc-fragment is, recognised through loops of the C-terminal receptor domain of the, FcgammaRIII. As the overall structure of the FcRs and their Ig ligands are, very similar we modelled the Ig complexes with FcgammaRI, FcgammaRII and, FcepsilonRIalpha based on the FcgammaRIII/hIgG1-Fc-fragment structure. The, obtained models are consistent with the observed biochemical data and may, explain the observed specificity and affinities.

Disease

Known diseases associated with this structure: Lupus nephritis, susceptibility to OMIM:[146790]

About this Structure

1H9V is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Molecular basis for immune complex recognition: a comparison of Fc-receptor structures., Sondermann P, Kaiser J, Jacob U, J Mol Biol. 2001 Jun 8;309(3):737-49. PMID:11397093

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