1ba9
From Proteopedia
(New page: 200px<br /> <applet load="1ba9" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ba9" /> '''THE SOLUTION STRUCTURE OF REDUCED MONOMERIC...) |
|||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1BA9 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with ZN and CU1 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BA9 OCA]]. | + | 1BA9 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with ZN and CU1 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1]]. Structure known Active Sites: CU and ZN. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BA9 OCA]]. |
==Reference== | ==Reference== | ||
| Line 14: | Line 14: | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| + | [[Category: Superoxide dismutase]] | ||
[[Category: Banci, L.]] | [[Category: Banci, L.]] | ||
[[Category: Benedetto, M.]] | [[Category: Benedetto, M.]] | ||
| Line 27: | Line 28: | ||
[[Category: superoxide dismutase]] | [[Category: superoxide dismutase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:04:42 2007'' |
Revision as of 10:59, 30 October 2007
|
THE SOLUTION STRUCTURE OF REDUCED MONOMERIC SUPEROXIDE DISMUTASE, NMR, 36 STRUCTURES
Overview
Copper, zinc superoxide dismutase is a dimeric enzyme, and it has been, shown that no cooperativity between the two subunits of the dimer is, operative. The substitution of two hydrophobic residues, Phe 50 and Gly, 51, with two Glu's at the interface region has disrupted the quaternary, structure of the protein, thus producing a soluble monomeric form., However, this monomeric form was found to have an activity lower than that, of the native dimeric species (10%). To answer the fundamental question of, the role of the quaternary structure in the catalytic process of, superoxide dismutase, we have determined the solution structure of the, reduced monomeric mutant through NMR spectroscopy. Another fundamental, issue with respect to the enzymatic mechanism is the coordination of, reduced ... [(full description)]
About this Structure
1BA9 is a [Single protein] structure of sequence from [Homo sapiens] with ZN and CU1 as [ligands]. Active as [Superoxide dismutase], with EC number [1.15.1.1]. Structure known Active Sites: CU and ZN. Full crystallographic information is available from [OCA].
Reference
Solution structure of reduced monomeric Q133M2 copper, zinc superoxide dismutase (SOD). Why is SOD a dimeric enzyme?., Banci L, Benedetto M, Bertini I, Del Conte R, Piccioli M, Viezzoli MS, Biochemistry. 1998 Aug 25;37(34):11780-91. PMID:9718300
Page seeded by OCA on Tue Oct 30 13:04:42 2007
