Hormone

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Revision as of 00:38, 29 March 2012

UNDER DEVELOPMENT: This article is a work in progress, and is incomplete.   For the date when the most recent work on this article was done, click on the history tab above.

In the field of modern endocrinology, a hormone is any substance, generated either externally or internally, that operates via a receptor at the cellular level, which conveys to to the cell a message to stop, start, or modulate a cellular process.

Guide to Proteopedia Pages Concerning Hormones and Receptors

spinqualitylabelsall models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
FSH binding to the leucine-rich domain of Follicle Stimulating Hormone Receptor (1fl7 morphing to 1xwd, resolution 2.92Å)

Articles in Proteopedia concerning Hormone include:

To view automatically seeded indices concerning Hormone, see:

• Hormone
• Hormone Receptor
• Steroid receptor
• Steroid hormone receptor

Additional 3D Structures of Hormones and Hormone Receptors and Related Molecules

Angiotensinogen

2wxw, 2wxx, 2wxy, 2wxz, 2wy0, 2wy1, 2x0b - Angiotensinogen – human, rat, mouse

Chorionic Gonadotropin

1hrp - Chorionic Gonadotropin – human
1hcn - Chorionic Gonadotropin – human
1hd4 - Alpha-subunit of Chorionic Gonadotropin – human

Follicle-Stimulating Hormone

1fl7 - Follicle-Stimulating Hormone – human
1xwd - Human Follicle Stimulating Hormone complexed with its Receptor – human

Glucocorticoid

3mne, 3mno, 3mnp - Glucocorticoid Receptor Ligand-binding Domain – human

Growth Hormone

3hhr - Growth Hormone complexed with the extracellular portion of its receptor - human
1hwh - Growth Hormone Mutant G120R complexed with the extracellular portion of its receptor - human
1bp3 - Growth Hormone complexed with the prolactin receptor - human
3mjg, 3mjk - Platelet-derived Growth Factor/Propeptide Complex and a Platelet-Derived Growth Factor/Receptor Complex – human
Vascular Endothelial Growth Factor – human and others, see Vascular Endothelial Growth Factor Structures
Vascular Endothelial Growth Factor Receptor – human, see Vascular Endothelial Growth Factor Receptor Structures
2xdg - Extracellular Domain of Human Growth Hormone Releasing Hormone Receptor – human

Insulin

3ir0 , 1mso , 1trz , 2qiu , 2r34, 2r35 , 2r36, 3ilg, 2kjj , 2kju - Insulin – human
3nw5, 3nw6, 3nw7 - insulin-like growth factor 1 receptor – human
3loh, 2dtg - insulin receptor ectodomain – human

Progesterone

3hq5,3g8n, 3g8o, 3hq5 - Progesterone – human

Thyroid-Stimulating hormone

3g04 - TSH receptor in complex with a thyroid-stimulating autoantibody – human

Thyroxine

2xn3, 2xn5, 2xn6, 2xn7 - Thyroxine-binding Globulin – human

Farnesoid X Receptor

3olf, 3omk, 3omm, 3oof, 3ook, 3okh, 3oki - Farnesoid X Receptor – human

PACAP/glucagon family of peptide hormones

3n94 - PAC1R, receptor of pituitary adenylate cyclase activating polypeptide, is a case of a crystal structure disagreeing with the NMR structure 2jod and vice versa
2jod - Pituitary adenylate cyclase-activating polypeptide (residues 6'-38') complexed to the extracellular domain of the human splice variant hPAC1-RS determined by NMR - human

See Also

• Cancer
• Membrane proteins
• G protein-coupled receptors

External Resources

• Sequence-Structure-Function-Analysis of Glycoprotein Hormone Receptors
• The GPCR-SSFE Database: A Homology Model Resource for G-Protein Coupled Receptors
• The feature on Growth Hormone by Shuchismita Dutta and David S. Goodsell for the April 2004 RCSB PDB Molecule of the Month.
• NeuroPedia, a neuropeptide database and spectral libraryCystine-knot growth factor

Cyclic cystine knot Cystine knot superfamily Cystine knot motif