1hyi
From Proteopedia
(New page: 200px<br /> <applet load="1hyi" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hyi" /> '''SOLUTION STRUCTURE OF THE EEA1 FYVE DOMAIN ...) |
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'''SOLUTION STRUCTURE OF THE EEA1 FYVE DOMAIN COMPLEXED WITH INOSITOL 1,3-BISPHOSPHATE'''<br /> | '''SOLUTION STRUCTURE OF THE EEA1 FYVE DOMAIN COMPLEXED WITH INOSITOL 1,3-BISPHOSPHATE'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1HYI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN and ITP as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1HYI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=ITP:'>ITP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HYI OCA]. |
==Reference== | ==Reference== | ||
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[[Category: zinc cluster]] | [[Category: zinc cluster]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:58:42 2008'' |
Revision as of 13:58, 15 February 2008
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SOLUTION STRUCTURE OF THE EEA1 FYVE DOMAIN COMPLEXED WITH INOSITOL 1,3-BISPHOSPHATE
Contents |
Overview
The recruitment of trafficking and signaling proteins to membranes, containing phosphatidylinositol 3-phosphate [PtdIns(3)P] is mediated by, FYVE domains. Here, the solution structure of the FYVE domain of the early, endosome antigen 1 protein (EEA1) in the free state was compared with the, structures of the domain complexed with PtdIns(3)P and mixed micelles. The, multistep binding mechanism involved nonspecific insertion of a, hydrophobic loop into the lipid bilayer, positioning and activating the, binding pocket. Ligation of PtdIns(3)P then induced a global structural, change, drawing the protein termini over the bound phosphoinositide by, extension of a hinge. Specific recognition of the 3-phosphate was, determined indirectly and directly by two clusters of conserved arginines.
Disease
Known disease associated with this structure: Spastic paraplegia 33 OMIM:[610243]
About this Structure
1HYI is a Single protein structure of sequence from Homo sapiens with and as ligands. Full crystallographic information is available from OCA.
Reference
Structural mechanism of endosome docking by the FYVE domain., Kutateladze T, Overduin M, Science. 2001 Mar 2;291(5509):1793-6. PMID:11230696
Page seeded by OCA on Fri Feb 15 15:58:42 2008
Categories: Homo sapiens | Single protein | Kutateladze, T. | Overduin, M. | ITP | ZN | Alpha helix | Beta sheet | Ptdins(3)p | Zinc cluster
