1hzm
From Proteopedia
(New page: 200px<br /> <applet load="1hzm" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hzm" /> '''STRUCTURE OF ERK2 BINDING DOMAIN OF MAPK PH...) |
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'''STRUCTURE OF ERK2 BINDING DOMAIN OF MAPK PHOSPHATASE MKP-3: STRUCTURAL INSIGHTS INTO MKP-3 ACTIVATION BY ERK2'''<br /> | '''STRUCTURE OF ERK2 BINDING DOMAIN OF MAPK PHOSPHATASE MKP-3: STRUCTURAL INSIGHTS INTO MKP-3 ACTIVATION BY ERK2'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1HZM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1HZM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HZM OCA]. |
==Reference== | ==Reference== | ||
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[[Category: hydrolase]] | [[Category: hydrolase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:58:54 2008'' |
Revision as of 13:58, 15 February 2008
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STRUCTURE OF ERK2 BINDING DOMAIN OF MAPK PHOSPHATASE MKP-3: STRUCTURAL INSIGHTS INTO MKP-3 ACTIVATION BY ERK2
Overview
MAP kinases (MAPKs), which control mitogenic signal transduction in all, eukaryotic organisms, are inactivated by dual specificity MAPK, phosphatases (MKPs). MKP-3, a prototypical MKP, achieves substrate, specificity through its N-terminal domain binding to the MAPK ERK2, resulting in the activation of its C-terminal phosphatase domain. The, solution structure and biochemical analysis of the ERK2 binding (EB), domain of MKP-3 show that regions that are essential for ERK2 binding, partly overlap with its sites that interact with the C-terminal catalytic, domain, and that these interactions are functionally coupled to the active, site residues of MKP-3. Our findings suggest a novel mechanism by which, the EB domain binding to ERK2 is transduced to cause a conformational, change of the C-terminal catalytic domain, resulting in the enzymatic, activation of MKP-3.
About this Structure
1HZM is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Solution structure of ERK2 binding domain of MAPK phosphatase MKP-3: structural insights into MKP-3 activation by ERK2., Farooq A, Chaturvedi G, Mujtaba S, Plotnikova O, Zeng L, Dhalluin C, Ashton R, Zhou MM, Mol Cell. 2001 Feb;7(2):387-99. PMID:11239467
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