1ice

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(New page: 200px<br /> <applet load="1ice" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ice, resolution 2.60&Aring;" /> '''STRUCTURE AND MECHA...)
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caption="1ice, resolution 2.60&Aring;" />
'''STRUCTURE AND MECHANISM OF INTERLEUKIN-1BETA CONVERTING ENZYME'''<br />
'''STRUCTURE AND MECHANISM OF INTERLEUKIN-1BETA CONVERTING ENZYME'''<br />
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==About this Structure==
==About this Structure==
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1ICE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with ACE as [http://en.wikipedia.org/wiki/ligand ligand]. The following page contains interesting information on the relation of 1ICE with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb56_1.html Caspases]]. Active as [http://en.wikipedia.org/wiki/Caspase-1 Caspase-1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.36 3.4.22.36] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1ICE OCA].
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1ICE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=ACE:'>ACE</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. The following page contains interesting information on the relation of 1ICE with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb56_1.html Caspases]]. Active as [http://en.wikipedia.org/wiki/Caspase-1 Caspase-1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.36 3.4.22.36] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ICE OCA].
==Reference==
==Reference==
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[[Category: cytokine]]
[[Category: cytokine]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 17:28:43 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:00:54 2008''

Revision as of 14:00, 15 February 2008

Image:1ice.jpg

1ice, resolution 2.60Å

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STRUCTURE AND MECHANISM OF INTERLEUKIN-1BETA CONVERTING ENZYME

Overview

Interleukin-1 beta converting enzyme (ICE) processes an inactive precursor, to the proinflammatory cytokine, interleukin-1 beta, and may regulate, programmed cell death in neuronal cells. The high-resolution structure of, human ICE in complex with an inhibitor has been determined by X-ray, diffraction. The structure confirms the relationship between human ICE and, cell-death proteins in other organisms. The active site spans both the 10, and 20K subunits, which associate to form a tetramer, suggesting a, mechanism for ICE autoactivation.

About this Structure

1ICE is a Single protein structure of sequence from [1] with as ligand. The following page contains interesting information on the relation of 1ICE with [Caspases]. Active as Caspase-1, with EC number 3.4.22.36 Full crystallographic information is available from OCA.

Reference

Structure and mechanism of interleukin-1 beta converting enzyme., Wilson KP, Black JA, Thomson JA, Kim EE, Griffith JP, Navia MA, Murcko MA, Chambers SP, Aldape RA, Raybuck SA, et al., Nature. 1994 Jul 28;370(6487):270-5. PMID:8035875

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