1ijr
From Proteopedia
(New page: 200px<br /> <applet load="1ijr" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ijr, resolution 2.2Å" /> '''Crystal structure of...) |
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| - | [[Image:1ijr. | + | [[Image:1ijr.jpg|left|200px]]<br /><applet load="1ijr" size="350" color="white" frame="true" align="right" spinBox="true" |
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caption="1ijr, resolution 2.2Å" /> | caption="1ijr, resolution 2.2Å" /> | ||
'''Crystal structure of LCK SH2 complexed with nonpeptide phosphotyrosine mimetic'''<br /> | '''Crystal structure of LCK SH2 complexed with nonpeptide phosphotyrosine mimetic'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1IJR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CC0 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] Full crystallographic information is available from [http:// | + | 1IJR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CC0:'>CC0</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IJR OCA]. |
==Reference== | ==Reference== | ||
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[[Category: tyrosine-protein kinase]] | [[Category: tyrosine-protein kinase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:01:42 2008'' |
Revision as of 14:01, 15 February 2008
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Crystal structure of LCK SH2 complexed with nonpeptide phosphotyrosine mimetic
Contents |
Overview
The novel phosphotyrosine (pTyr) mimetic, 4'-carboxymethyloxy-3'-phosphonophenylalanine (Cpp) has been designed and, incorporated into a series of nonpeptide inhibitors of the SH2 domain of, pp60(c-Src) (Src) tyrosine kinase. A 2.2 A X-ray crystal structure of 1a, bound to a mutant form of Lck SH2 domain provides insight regarding the, structure-activity relationships and supports the design concept of this, new pTyr mimetic.
Disease
Known disease associated with this structure: SCID due to LCK deficiency OMIM:[153390]
About this Structure
1IJR is a Single protein structure of sequence from Homo sapiens with as ligand. Active as Transferase, with EC number and 2.7.10.2 2.7.10.1 and 2.7.10.2 Full crystallographic information is available from OCA.
Reference
A novel phosphotyrosine mimetic 4'-carboxymethyloxy-3'-phosphonophenylalanine (Cpp): exploitation in the design of nonpeptide inhibitors of pp60(Src) SH2 domain., Kawahata N, Yang MG, Luke GP, Shakespeare WC, Sundaramoorthi R, Wang Y, Johnson D, Merry T, Violette S, Guan W, Bartlett C, Smith J, Hatada M, Lu X, Dalgarno DC, Eyermann CJ, Bohacek RS, Sawyer TK, Bioorg Med Chem Lett. 2001 Sep 3;11(17):2319-23. PMID:11527723
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