1ijv
From Proteopedia
(New page: 200px<br /> <applet load="1ijv" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ijv, resolution 1.20Å" /> '''HUMAN BETA-DEFENSIN...) |
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| - | [[Image:1ijv. | + | [[Image:1ijv.jpg|left|200px]]<br /><applet load="1ijv" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1ijv" size=" | + | |
caption="1ijv, resolution 1.20Å" /> | caption="1ijv, resolution 1.20Å" /> | ||
'''HUMAN BETA-DEFENSIN-1'''<br /> | '''HUMAN BETA-DEFENSIN-1'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1IJV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with SO4, BR and K as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1IJV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=BR:'>BR</scene> and <scene name='pdbligand=K:'>K</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IJV OCA]. |
==Reference== | ==Reference== | ||
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[[Category: human beta-defensin-1]] | [[Category: human beta-defensin-1]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:01:49 2008'' |
Revision as of 14:01, 15 February 2008
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HUMAN BETA-DEFENSIN-1
Overview
Defensins are a class of small cationic peptides found in higher organisms, that serve as both antimicrobial and cell signaling molecules. The exact, mechanism of the antimicrobial activity of defensins is not known, but two, models have been postulated, one involving pore formation and the other, involving nonspecific electrostatic interaction with the bacterial, membrane. Here we report the high resolution structures of human, beta-defensin-1 (hBD1) in two crystallographic space groups. The structure, of a single molecule is very similar to that of human beta-defensin-2, (hBD2), confirming the presence of an N-terminal alpha-helix. However, while the packing of hBD1 is conserved across both space groups, there is, no evidence for any larger quaternary structure similar to octameric hBD2., Furthermore, the topology of hBD1 dimers that are formed between monomers, in the asymmetric unit is distinct from both hBD2 and other mammalian, alpha-defensins. The structures of hBD1 and hBD2 provide a first step, toward understanding the structural basis of antimicrobial and chemotactic, properties of human beta-defensins.
About this Structure
1IJV is a Single protein structure of sequence from [1] with , and as ligands. Full crystallographic information is available from OCA.
Reference
The structure of human beta-defensin-1: new insights into structural properties of beta-defensins., Hoover DM, Chertov O, Lubkowski J, J Biol Chem. 2001 Oct 19;276(42):39021-6. Epub 2001 Aug 2. PMID:11486002
Page seeded by OCA on Fri Feb 15 16:01:49 2008
Categories: Single protein | Hoover, D.M. | Lubkowski, J. | BR | K | SO4 | Beta-defensin | Defensin | Human beta-defensin-1
