1j2x
From Proteopedia
(New page: 200px<br /> <applet load="1j2x" size="450" color="white" frame="true" align="right" spinBox="true" caption="1j2x, resolution 2.00Å" /> '''Crystal structure o...) |
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caption="1j2x, resolution 2.00Å" /> | caption="1j2x, resolution 2.00Å" /> | ||
'''Crystal structure of RAP74 C-terminal domain complexed with FCP1 C-terminal peptide'''<br /> | '''Crystal structure of RAP74 C-terminal domain complexed with FCP1 C-terminal peptide'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1J2X is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 and ZN as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1J2X is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J2X OCA]. |
==Reference== | ==Reference== | ||
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[[Category: winged-helix domain]] | [[Category: winged-helix domain]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:04:58 2008'' |
Revision as of 14:04, 15 February 2008
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Crystal structure of RAP74 C-terminal domain complexed with FCP1 C-terminal peptide
Contents |
Overview
After mRNA transcription termination in eukaryotes, the, hyperphosphorylated form of RNA polymerase II (pol II0) must be recycled, by TFIIF-associating C-terminal domain phosphatase (FCP1), the phosphatase, responsible for dephosphorylating the C-terminal domain of the largest, polymerase subunit. Transcription factor (TF)-IIF stimulates the activity, of FCP1, and the RNA polymerase II-associating protein 74 subunit of TFIIF, forms a complex with FCP1 in both human and yeast. Here, we report a, cocrystal structure of the winged-helix domain of human RNA polymerase, II-associating protein 74 bound to the alpha-helical C terminus of human, FCP1 (residues 944-961). These results illustrate the molecular mechanism, by which TFIIF efficiently recruits FCP1 to the pol II transcription, machinery for recycling of the polymerase.
Disease
Known disease associated with this structure: Congenital cataracts, facial dysmorphism, and neuropathy OMIM:[604927]
About this Structure
1J2X is a Protein complex structure of sequences from Homo sapiens with and as ligands. Full crystallographic information is available from OCA.
Reference
Molecular mechanism of recruitment of TFIIF- associating RNA polymerase C-terminal domain phosphatase (FCP1) by transcription factor IIF., Kamada K, Roeder RG, Burley SK, Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2296-9. Epub 2003 Feb 18. PMID:12591941
Page seeded by OCA on Fri Feb 15 16:04:58 2008
Categories: Homo sapiens | Protein complex | Burley, S.K. | Kamada, K. | Roeder, R.G. | SO4 | ZN | Ctd | Fcp1 | General transcription factor | Phosphatase | Rap30 | Rap74 | Rna polymerase ii | Tfiif | Winged-helix domain
