Carbonyl reductase
From Proteopedia
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| + | {{STRUCTURE_1cyd| PDB=1cyd | SIZE=400| SCENE= |right|CAPTION=Mouse carbonyl reductase complex with 2-propanol and NADPH, [[1cyd]] }} | ||
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'''Carbonyl reductase ternary complex with NADPH''' | '''Carbonyl reductase ternary complex with NADPH''' | ||
| - | [[1cyd]] – CBR + 2- | + | [[1cyd]] – CBR + 2-propanol + NADPH – mouse<BR /> |
[[1wma]] – hCBR1 + hydroxyl-PP + NADPH<BR /> | [[1wma]] – hCBR1 + hydroxyl-PP + NADPH<BR /> | ||
[[2pfg]] - hCBR1 + bicycle-undecane + NADPH<BR /> | [[2pfg]] - hCBR1 + bicycle-undecane + NADPH<BR /> | ||
[[3bhj]] - hCBR1 + glutathione + NADPH<BR /> | [[3bhj]] - hCBR1 + glutathione + NADPH<BR /> | ||
[[3bhm]] - hCBR1 + hydroxymethylglutathione + NADPH<BR /> | [[3bhm]] - hCBR1 + hydroxymethylglutathione + NADPH<BR /> | ||
Revision as of 09:08, 10 April 2012
Carbonyl reductase (CBR) catalyzes the reaction converting R-CHOH-R and NADP to R-CO-R’ and NADPH. CBR has wide substrate specificity oxidoreductase activity. CBR has similar properties to aldose reductase and aldehyde reductase.
3D structures of carbonyl reductase
1zze – CBR – Sporidiobolus salmonicolor
3ctm – CBR – Candida parapsilosis
Carbonyl reductase binary complex with NADPH
3bhi - hCBR1 + NADPH - human
2hrb – hCBR3 + NADPH
Carbonyl reductase ternary complex with NADPH
1cyd – CBR + 2-propanol + NADPH – mouse
1wma – hCBR1 + hydroxyl-PP + NADPH
2pfg - hCBR1 + bicycle-undecane + NADPH
3bhj - hCBR1 + glutathione + NADPH
3bhm - hCBR1 + hydroxymethylglutathione + NADPH
