1j7v
From Proteopedia
(New page: 200px<br /> <applet load="1j7v" size="450" color="white" frame="true" align="right" spinBox="true" caption="1j7v, resolution 2.9Å" /> '''HUMAN IL-10 / IL-10R...) |
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| - | [[Image:1j7v. | + | [[Image:1j7v.jpg|left|200px]]<br /><applet load="1j7v" size="350" color="white" frame="true" align="right" spinBox="true" |
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caption="1j7v, resolution 2.9Å" /> | caption="1j7v, resolution 2.9Å" /> | ||
'''HUMAN IL-10 / IL-10R1 COMPLEX'''<br /> | '''HUMAN IL-10 / IL-10R1 COMPLEX'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1J7V is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1J7V is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J7V OCA]. |
==Reference== | ==Reference== | ||
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[[Category: interleukin-10]] | [[Category: interleukin-10]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:05:47 2008'' |
Revision as of 14:05, 15 February 2008
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HUMAN IL-10 / IL-10R1 COMPLEX
Contents |
Overview
Interleukin 10 (IL-10) is a dimeric cytokine that plays a central role in, suppressing inflammatory responses. These activities are dependent on the, interaction of IL-10 with its high-affinity receptor (IL-10R1). This, intermediate complex must subsequently recruit the low-affinity IL-10R2, chain before cell signaling can occur. Here we report the 2.9 A crystal, structure of IL-10 bound to a soluble form of IL-10R1 (sIL-10R1). The, complex consists of two IL-10s and four sIL-10R1 molecules. Several, residues in the IL-10/sIL-10R1 interface are conserved in all IL-10, homologs and their receptors. The data suggests that formation of the, active IL-10 signaling complex occurs by a novel molecular recognition, paradigm where IL-10R1 and IL-10R2 both recognize the same binding site on, IL-10.
Disease
Known diseases associated with this structure: Graft-versus-host disease, protection against OMIM:[124092], HIV-1, susceptibility to OMIM:[124092], Rheumatoid arthritis, progression of OMIM:[124092]
About this Structure
1J7V is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site., Josephson K, Logsdon NJ, Walter MR, Immunity. 2001 Jul;15(1):35-46. PMID:11485736
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