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1unr

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(New page: 200px<br /> <applet load="1unr" size="450" color="white" frame="true" align="right" spinBox="true" caption="1unr, resolution 1.25&Aring;" /> '''CRYSTAL STRUCTURE O...)
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==About this Structure==
==About this Structure==
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1UNR is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with SO4 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UNR OCA]].
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1UNR is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with SO4 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UNR OCA]].
==Reference==
==Reference==
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[[Category: pleckstrin homology]]
[[Category: pleckstrin homology]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 20:10:38 2007''
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:06:36 2007''

Revision as of 11:01, 30 October 2007

Image:1unr.gif

1unr, resolution 1.25Å

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CRYSTAL STRUCTURE OF THE PH DOMAIN OF PKB ALPHA IN COMPLEX WITH A SULFATE MOLECULE

Overview

Protein kinase B (PKB/Akt) is a key regulator of cell growth, proliferation and metabolism. It possesses an N-terminal pleckstrin, homology (PH) domain that interacts with equal affinity with the second, messengers PtdIns(3,4,5)P3 and PtdIns(3,4)P2, generated through insulin, and growth factor-mediated activation of phosphoinositide 3-kinase (PI3K)., The binding of PKB to PtdIns(3,4,5)P3/PtdIns(3,4)P2 recruits PKB from the, cytosol to the plasma membrane and is also thought to induce a, conformational change that converts PKB into a substrate that can be, activated by the phosphoinositide-dependent kinase 1 (PDK1). In this study, we describe two high-resolution crystal structures of the PH domain of, PKBalpha in a noncomplexed form and compare this to a new atomic, resolution (0.98 A, ... [(full description)]

About this Structure

1UNR is a [Single protein] structure of sequence from [Homo sapiens] with SO4 as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change., Milburn CC, Deak M, Kelly SM, Price NC, Alessi DR, Van Aalten DM, Biochem J. 2003 Nov 1;375(Pt 3):531-8. PMID:12964941

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