1jid
From Proteopedia
(New page: 200px<br /> <applet load="1jid" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jid, resolution 1.80Å" /> '''Human SRP19 in comp...) |
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| - | [[Image:1jid. | + | [[Image:1jid.jpg|left|200px]]<br /><applet load="1jid" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1jid" size=" | + | |
caption="1jid, resolution 1.80Å" /> | caption="1jid, resolution 1.80Å" /> | ||
'''Human SRP19 in complex with helix 6 of Human SRP RNA'''<br /> | '''Human SRP19 in complex with helix 6 of Human SRP RNA'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1JID is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with MG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1JID is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JID OCA]. |
==Reference== | ==Reference== | ||
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[[Category: signal recognition particle (srp)]] | [[Category: signal recognition particle (srp)]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:07:35 2008'' |
Revision as of 14:07, 15 February 2008
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Human SRP19 in complex with helix 6 of Human SRP RNA
Overview
The signal recognition particle (SRP) is a universally conserved, ribonucleoprotein complex that mediates the cotranslational targeting of, secretory and membrane proteins to cellular membranes. A crucial early, step in SRP assembly in archaea and eukarya is the binding of protein, SRP19 to specific sites on SRP RNA. Here we report the 1.8 angstrom, resolution crystal structure of human SRP19 in complex with its primary, binding site on helix 6 of SRP RNA, which consists of a stem-loop, structure closed by an unusual GGAG tetraloop. Protein-RNA interactions, are mediated by the specific recognition of a widened major groove and the, tetraloop without any direct protein-base contacts and include a complex, network of highly ordered water molecules. A model of the assembly of the, SRP core comprising SRP19, SRP54, and SRP RNA based on crystallographic, and biochemical data is proposed.
About this Structure
1JID is a Protein complex structure of sequences from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of an early protein-RNA assembly complex of the signal recognition particle., Wild K, Sinning I, Cusack S, Science. 2001 Oct 19;294(5542):598-601. PMID:11641499
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