1un4
From Proteopedia
(New page: 200px<br /> <applet load="1un4" size="450" color="white" frame="true" align="right" spinBox="true" caption="1un4, resolution 2.10Å" /> '''CRYSTAL STRUCTURE O...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1UN4 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with CIT as [[http://en.wikipedia.org/wiki/ligand ligand]]. This structure superseeds the now removed PDB entry 1H0E. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UN4 OCA]]. | + | 1UN4 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with CIT as [[http://en.wikipedia.org/wiki/ligand ligand]]. This structure superseeds the now removed PDB entry 1H0E. Active as [[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5]]. Structure known Active Site: CIT. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UN4 OCA]]. |
==Reference== | ==Reference== | ||
Crystallographic studies on structural features that determine the enzymatic specificity and potency of human angiogenin: Thr44, Thr80, and residues 38-41., Holloway DE, Chavali GB, Hares MC, Baker MD, Subbarao GV, Shapiro R, Acharya KR, Biochemistry. 2004 Feb 10;43(5):1230-41. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14756559 14756559] | Crystallographic studies on structural features that determine the enzymatic specificity and potency of human angiogenin: Thr44, Thr80, and residues 38-41., Holloway DE, Chavali GB, Hares MC, Baker MD, Subbarao GV, Shapiro R, Acharya KR, Biochemistry. 2004 Feb 10;43(5):1230-41. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14756559 14756559] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| + | [[Category: Pancreatic ribonuclease]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Acharya, K.R.]] | [[Category: Acharya, K.R.]] | ||
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[[Category: ribonuclease]] | [[Category: ribonuclease]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:07:03 2007'' |
Revision as of 11:02, 30 October 2007
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CRYSTAL STRUCTURE OF HUMAN ANGIOGENIN VARIANT T80A
Overview
Human angiogenin (Ang) is a potent inducer of blood vessel formation and, is a member of the pancreatic ribonuclease superfamily. Its enzymatic, activity is unusually weak and biased toward cleavage after cytidine, nucleotides. As part of an ongoing investigation into the structural basis, of Ang's characteristic activity, we have determined the crystal, structures of three Ang variants having novel activity. (i) The structure, of T44D-Ang indicates that Asp44 can participate directly in pyrimidine, binding and that the intrinsic hydrogen-bonding capability of this residue, largely governs the pyrimidine specificity of this variant. Unexpectedly, the mutation also causes the most extensive disruption of the C-terminus, seen in any Ang variant thus far. This allows the side chain of Arg101 ... [(full description)]
About this Structure
1UN4 is a [Single protein] structure of sequence from [Homo sapiens] with CIT as [ligand]. This structure superseeds the now removed PDB entry 1H0E. Active as [Pancreatic ribonuclease], with EC number [3.1.27.5]. Structure known Active Site: CIT. Full crystallographic information is available from [OCA].
Reference
Crystallographic studies on structural features that determine the enzymatic specificity and potency of human angiogenin: Thr44, Thr80, and residues 38-41., Holloway DE, Chavali GB, Hares MC, Baker MD, Subbarao GV, Shapiro R, Acharya KR, Biochemistry. 2004 Feb 10;43(5):1230-41. PMID:14756559
Page seeded by OCA on Tue Oct 30 13:07:03 2007
