1jwh
From Proteopedia
(New page: 200px<br /> <applet load="1jwh" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jwh, resolution 3.10Å" /> '''Crystal Structure o...) |
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caption="1jwh, resolution 3.10Å" /> | caption="1jwh, resolution 3.10Å" /> | ||
'''Crystal Structure of Human Protein Kinase CK2 Holoenzyme'''<br /> | '''Crystal Structure of Human Protein Kinase CK2 Holoenzyme'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1JWH is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with PO4, ZN and ANP as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http:// | + | 1JWH is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=ANP:'>ANP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JWH OCA]. |
==Reference== | ==Reference== | ||
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[[Category: protein kinase ck2]] | [[Category: protein kinase ck2]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:09:50 2008'' |
Revision as of 14:09, 15 February 2008
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Crystal Structure of Human Protein Kinase CK2 Holoenzyme
Overview
The crystal structure of a fully active form of human protein kinase CK2, (casein kinase 2) consisting of two C-terminally truncated catalytic and, two regulatory subunits has been determined at 3.1 A resolution. In the, CK2 complex the regulatory subunits form a stable dimer linking the two, catalytic subunits, which make no direct contact with one another. Each, catalytic subunit interacts with both regulatory chains, predominantly via, an extended C-terminal tail of the regulatory subunit. The CK2 structure, is consistent with its constitutive activity and with a flexible role of, the regulatory subunit as a docking partner for various protein kinases., Furthermore it shows an inter-domain mobility in the catalytic subunit, known to be functionally important in protein kinases and detected here, for the first time directly within one crystal structure.
About this Structure
1JWH is a Protein complex structure of sequences from Homo sapiens with , and as ligands. Active as Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 Full crystallographic information is available from OCA.
Reference
Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme., Niefind K, Guerra B, Ermakowa I, Issinger OG, EMBO J. 2001 Oct 1;20(19):5320-31. PMID:11574463
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