1uns
From Proteopedia
(New page: 200px<br /> <applet load="1uns" size="450" color="white" frame="true" align="right" spinBox="true" caption="1uns, resolution 2.0Å" /> '''IDENTIFICATION OF A ...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1UNS is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]] with ZN as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UNS OCA]]. | + | 1UNS is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]] with ZN as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UNS OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: zinc-binding site]] | [[Category: zinc-binding site]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:07:11 2007'' |
Revision as of 11:02, 30 October 2007
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IDENTIFICATION OF A SECONDARY ZINC-BINDING SITE IN STAPHYLOCOCCAL ENTEROTOXIN C2: IMPLICATIONS FOR SUPERANTIGEN RECOGNITION
Overview
The previously determined crystal structure of the superantigen, staphylococcal enterotoxin C2 (SEC2) showed binding of a single zinc ion, located between the N- and C-terminal domains. Here we present the crystal, structure of SEC2 determined to 2.0 A resolution in the presence of, additional zinc. The structure revealed the presence of a secondary, zinc-binding site close to the major histocompatibility complex, (MHC)-binding site of the toxin and some 28 A away from the primary, zinc-binding site of the toxin found in previous studies. T cell, stimulation assays showed that varying the concentration of zinc ions, present affected the activity of the toxin and we observed that high zinc, concentrations considerably inhibited T cell responses. This indicates, that SEC2 may have multiple ... [(full description)]
About this Structure
1UNS is a [Single protein] structure of sequence from [Staphylococcus aureus] with ZN as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Identification of a secondary zinc-binding site in staphylococcal enterotoxin C2. Implications for superantigen recognition., Papageorgiou AC, Baker MD, McLeod JD, Goda SK, Manzotti CN, Sansom DM, Tranter HS, Acharya KR, J Biol Chem. 2004 Jan 9;279(2):1297-303. Epub 2003 Oct 14. PMID:14559915
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