1k36
From Proteopedia
(New page: 200px<br /> <applet load="1k36" size="450" color="white" frame="true" align="right" spinBox="true" caption="1k36" /> '''NMR Structure of human Epiregulin'''<br /> ...) |
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| - | [[Image:1k36. | + | [[Image:1k36.jpg|left|200px]]<br /><applet load="1k36" size="350" color="white" frame="true" align="right" spinBox="true" |
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'''NMR Structure of human Epiregulin'''<br /> | '''NMR Structure of human Epiregulin'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1K36 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1K36 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K36 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: egf-like fold]] | [[Category: egf-like fold]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:11:05 2008'' |
Revision as of 14:11, 15 February 2008
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NMR Structure of human Epiregulin
Overview
Epiregulin (EPR), a novel member of epidermal growth factor (EGF) family, is a ligand for ErbB-1 and ErbB-4 receptors. The binding affinity of EPR, for the receptors is lower than those of other EGF-family ligands. The, solution structure of EPR was determined using two-dimensional nuclear, magnetic resonance spectroscopy. The secondary structure in the C-terminal, domain of EPR is different from other EGF-family ligands because of the, lack of hydrogen bonds. The structural difference in the C-terminal domain, may provide an explanation for the reduced binding affinity of EPR to the, ErbB receptors.
About this Structure
1K36 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Solution structure of epiregulin and the effect of its C-terminal domain for receptor binding affinity., Sato K, Nakamura T, Mizuguchi M, Miura K, Tada M, Aizawa T, Gomi T, Miyamoto K, Kawano K, FEBS Lett. 2003 Oct 23;553(3):232-8. PMID:14572630
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