1cmv
From Proteopedia
(New page: 200px<br /> <applet load="1cmv" size="450" color="white" frame="true" align="right" spinBox="true" caption="1cmv, resolution 2.27Å" /> '''HUMAN CYTOMEGALOVIR...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1CMV is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/ | + | 1CMV is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Human_herpesvirus_5 Human herpesvirus 5]]. Structure known Active Sites: ACA and ACB. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1CMV OCA]]. |
==Reference== | ==Reference== | ||
Three-dimensional structure of human cytomegalovirus protease., Shieh HS, Kurumbail RG, Stevens AM, Stegeman RA, Sturman EJ, Pak JY, Wittwer AJ, Palmier MO, Wiegand RC, Holwerda BC, Stallings WC, Nature. 1996 Sep 19;383(6597):279-82. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8805708 8805708] | Three-dimensional structure of human cytomegalovirus protease., Shieh HS, Kurumbail RG, Stevens AM, Stegeman RA, Sturman EJ, Pak JY, Wittwer AJ, Palmier MO, Wiegand RC, Holwerda BC, Stallings WC, Nature. 1996 Sep 19;383(6597):279-82. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8805708 8805708] | ||
| - | [[Category: Human | + | [[Category: Human herpesvirus 5]] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Holwerda, B.C.]] | [[Category: Holwerda, B.C.]] | ||
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[[Category: serine protease]] | [[Category: serine protease]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:08:15 2007'' |
Revision as of 11:03, 30 October 2007
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HUMAN CYTOMEGALOVIRUS PROTEASE
Overview
Herpesviruses encode a serine protease that specifically cleaves assembly, protein. This protease is critical for replication, and represents a new, target for antiviral drug design. Here we report the three-dimensional, structure of the protease from human cytomegalovirus (hCMV) at 2.27, angstroms resolution. The structure reveals a unique fold and new, catalytic strategy for cleavage. The monomer fold of the enzyme, a, seven-stranded beta-barrel encircled by a chain of helices that form the, carboxy terminus of the molecule, is unrelated to those observed in, classic serine proteases such as chymotrypsin and subtilisin. The serine, nucleophile at position 132 is activated by two juxtaposed histidine, residues at positions 63 and 157. Dimerization, which seems to be, necessary for ... [(full description)]
About this Structure
1CMV is a [Single protein] structure of sequence from [Human herpesvirus 5]. Structure known Active Sites: ACA and ACB. Full crystallographic information is available from [OCA].
Reference
Three-dimensional structure of human cytomegalovirus protease., Shieh HS, Kurumbail RG, Stevens AM, Stegeman RA, Sturman EJ, Pak JY, Wittwer AJ, Palmier MO, Wiegand RC, Holwerda BC, Stallings WC, Nature. 1996 Sep 19;383(6597):279-82. PMID:8805708
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