4dru

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'''Unreleased structure'''
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[[Image:4dru.jpg|left|200px]]
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The entry 4dru is ON HOLD until Paper Publication
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{{STRUCTURE_4dru| PDB=4dru | SCENE= }}
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Authors: Cummings, M.D., Vendeville, S.
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===HCV NS5B in complex with macrocyclic INDOLE INHIBITOR===
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Description: HCV NS5B in complex with macrocyclic INDOLE INHIBITOR
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{{ABSTRACT_PUBMED_22473861}}
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==About this Structure==
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[[4dru]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DRU OCA].
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==Reference==
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<ref group="xtra">PMID:022473861</ref><references group="xtra"/>
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[[Category: Hepatitis c virus]]
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[[Category: RNA-directed RNA polymerase]]
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[[Category: Cummings, M D.]]
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[[Category: Vendeville, S.]]
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[[Category: Hcv polymerase]]
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[[Category: Macrocycle inhibitor]]
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[[Category: Thumb domain]]
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[[Category: Transferase-inhibitor complex]]

Revision as of 07:50, 18 April 2012

Image:4dru.jpg

Template:STRUCTURE 4dru

HCV NS5B in complex with macrocyclic INDOLE INHIBITOR

Template:ABSTRACT PUBMED 22473861

About this Structure

4dru is a 2 chain structure with sequence from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

  • Cummings MD, Lin TI, Hu L, Tahri A, McGowan D, Amssoms K, Last S, Devogelaere B, Rouan MC, Vijgen L, Berke JM, Dehertogh P, Fransen E, Cleiren E, van der Helm L, Fanning G, Van Emelen K, Nyanguile O, Simmen K, Raboisson P, Vendeville S. Structure-Based Macrocyclization Yields Hepatitis C Virus NS5B Inhibitors with Improved Binding Affinities and Pharmacokinetic Properties. Angew Chem Int Ed Engl. 2012 Mar 30. doi: 10.1002/anie.201200110. PMID:22473861 doi:10.1002/anie.201200110

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OCA

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