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1lm5
From Proteopedia
(New page: 200px<br /> <applet load="1lm5" size="450" color="white" frame="true" align="right" spinBox="true" caption="1lm5, resolution 1.80Å" /> '''Structures of two i...) |
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caption="1lm5, resolution 1.80Å" /> | caption="1lm5, resolution 1.80Å" /> | ||
'''Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure'''<br /> | '''Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1LM5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1LM5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LM5 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: plakin repeat]] | [[Category: plakin repeat]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:19:11 2008'' |
Revision as of 14:19, 15 February 2008
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Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure
Contents |
Overview
Desmosomes are intercellular junctions in which cadherin cell adhesion, molecules are linked to the intermediate filament (IF) system. Desmoplakin, is a member of the plakin family of IF-binding proteins. The C-terminal, domain of desmoplakin (DPCT) mediates binding to IFs in desmosomes. The, DPCT sequence contains three regions, termed A, B and C, consisting of 4.5, copies of a 38-amino acid repeat motif. We demonstrate that these regions, form discrete subdomains that bind to IFs and report the crystal, structures of domains B and C. In contrast to the elongated structures, formed by other kinds of repeat motifs, the plakin repeats form a globular, structure with a unique fold. A conserved basic groove found on the domain, may represent an IF-binding site.
Disease
Known diseases associated with this structure: Arrhythmogenic right ventricular dysplasia 8 OMIM:[125647], Dilated cardiomyopathy with woolly hair and keratoderma OMIM:[125647], Epidermolysis bullosa, lethal acantholytic OMIM:[125647], Keratosis palmoplantaris striata II OMIM:[125647], Skin fragility-woolly hair syndrome OMIM:[125647]
About this Structure
1LM5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure., Choi HJ, Park-Snyder S, Pascoe LT, Green KJ, Weis WI, Nat Struct Biol. 2002 Aug;9(8):612-20. PMID:12101406
Page seeded by OCA on Fri Feb 15 16:19:11 2008
