User:Marvin O'Neal/Antibody OspA and OspB
From Proteopedia
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==Introduction== | ==Introduction== | ||
| - | The causative agent of [http://en.wikipedia.org/wiki/Lyme_disease|Lyme disease] is [http://en.wikipedia.org/wiki/Borrelia_burgdorferi| Borellia burgdorferi], a [http://en.wikipedia.org/wiki/Spirochaete| spirochaete] found in the gut of hard bodied ticks of genus ''[http://en.wikipedia.org/wiki/| Ixodes]''. A factor contributing to the severity of Lyme disease is its resistance to complement-dependent lysis. Complement independent killing is necessary in fighting the Borrelia burgdorferi. Certain Fragment Antigen Binding (fab) fragments of antibody are bactericidal even in the absence of a complement. The binding of specific fabs of IgG and IgM monoclonal antibodies to OspA and OspB of the | + | The causative agent of [http://en.wikipedia.org/wiki/Lyme_disease|Lyme disease] is ''[http://en.wikipedia.org/wiki/Borrelia_burgdorferi| Borellia burgdorferi]'', a [http://en.wikipedia.org/wiki/Spirochaete| spirochaete] found in the gut of hard bodied ticks of genus ''[http://en.wikipedia.org/wiki/| Ixodes]''. A factor contributing to the severity of Lyme disease is its resistance to complement-dependent lysis. Complement independent killing is necessary in fighting the ''Borrelia burgdorferi''. Certain Fragment Antigen Binding (fab) fragments of antibody are bactericidal even in the absence of a complement. The binding of specific fabs of IgG and IgM monoclonal antibodies to OspA and OspB of the ''Borrelia'' leads to a complement-independent lysis of the bacteria <ref>PMID:15864264</ref>. |
Revision as of 19:55, 23 April 2012
Contents |
Introduction
The causative agent of disease is Borellia burgdorferi, a spirochaete found in the gut of hard bodied ticks of genus Ixodes. A factor contributing to the severity of Lyme disease is its resistance to complement-dependent lysis. Complement independent killing is necessary in fighting the Borrelia burgdorferi. Certain Fragment Antigen Binding (fab) fragments of antibody are bactericidal even in the absence of a complement. The binding of specific fabs of IgG and IgM monoclonal antibodies to OspA and OspB of the Borrelia leads to a complement-independent lysis of the bacteria [1].
Interaction With OspB
1FJ1- OspB + H6831
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Lys-253
doing its thing.
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Homologous Structures in OspA=
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Christopher Smilios, Philip J. Pipitone, Safa Abdelhakim, Alexandros Konstantinidis, Jaime Prilusky
