1lwc
From Proteopedia
(New page: 200px<br /> <applet load="1lwc" size="450" color="white" frame="true" align="right" spinBox="true" caption="1lwc, resolution 2.62Å" /> '''CRYSTAL STRUCTURE O...) |
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caption="1lwc, resolution 2.62Å" /> | caption="1lwc, resolution 2.62Å" /> | ||
'''CRYSTAL STRUCTURE OF M184V MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE'''<br /> | '''CRYSTAL STRUCTURE OF M184V MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1LWC is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with PO4 and NVP as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] Full crystallographic information is available from [http:// | + | 1LWC is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=PO4:'>PO4</scene> and <scene name='pdbligand=NVP:'>NVP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LWC OCA]. |
==Reference== | ==Reference== | ||
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[[Category: nrti]] | [[Category: nrti]] | ||
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Revision as of 14:21, 15 February 2008
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CRYSTAL STRUCTURE OF M184V MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE
Overview
Six structures of human immunodeficiency virus type 1 (HIV-1) reverse, transcriptase (RT) containing combinations of resistance mutations for, zidovudine (AZT) (M41L and T215Y) or lamivudine (M184V) have been, determined as inhibitor complexes. Minimal conformational changes in the, polymerase or nonnucleoside RT inhibitor sites compared to the mutant RTMC, (D67N, K70R, T215F, and K219N) are observed, indicating that such changes, may occur only with certain combinations of mutations. Model building M41L, and T215Y into HIV-1 RT-DNA and docking in ATP that is utilized in the, pyrophosphorolysis reaction for AZT resistance indicates that some, conformational rearrangement appears necessary in RT for ATP to interact, simultaneously with the M41L and T215Y mutations.
About this Structure
1LWC is a Protein complex structure of sequences from Human immunodeficiency virus 1 with and as ligands. Active as RNA-directed DNA polymerase, with EC number 2.7.7.49 Full crystallographic information is available from OCA.
Reference
Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215., Chamberlain PP, Ren J, Nichols CE, Douglas L, Lennerstrand J, Larder BA, Stuart DI, Stammers DK, J Virol. 2002 Oct;76(19):10015-9. PMID:12208978
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