1m0z
From Proteopedia
(New page: 200px<br /> <applet load="1m0z" size="450" color="white" frame="true" align="right" spinBox="true" caption="1m0z, resolution 1.85Å" /> '''Crystal Structure o...) |
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caption="1m0z, resolution 1.85Å" /> | caption="1m0z, resolution 1.85Å" /> | ||
'''Crystal Structure of the von Willebrand Factor Binding Domain of Glycoprotein Ib alpha'''<br /> | '''Crystal Structure of the von Willebrand Factor Binding Domain of Glycoprotein Ib alpha'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1M0Z is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1M0Z is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M0Z OCA]. |
==Reference== | ==Reference== | ||
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[[Category: leucine-rich repeat]] | [[Category: leucine-rich repeat]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:21:40 2008'' |
Revision as of 14:21, 15 February 2008
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Crystal Structure of the von Willebrand Factor Binding Domain of Glycoprotein Ib alpha
Contents |
Overview
Transient interactions of platelet-receptor glycoprotein Ibalpha, (GpIbalpha) and the plasma protein von Willebrand factor (VWF) reduce, platelet velocity at sites of vascular damage and play a role in, haemostasis and thrombosis. Here we present structures of the GpIbalpha, amino-terminal domain and its complex with the VWF domain A1. In the, complex, GpIbalpha wraps around one side of A1, providing two contact, areas bridged by an area of solvated charge interaction. The structures, explain the effects of gain-of-function mutations related to bleeding, disorders and provide a model for shear-induced activation. These detailed, insights into the initial interactions in platelet adhesion are relevant, to the development of antithrombotic drugs.
Disease
Known diseases associated with this structure: Bernard-Soulier syndrome, type A OMIM:[606672], Nonarteritic anterior ischemic optic neuropathy, susceptibility to OMIM:[606672], von Willebrand disease, platelet-type OMIM:[606672]
About this Structure
1M0Z is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain., Huizinga EG, Tsuji S, Romijn RA, Schiphorst ME, de Groot PG, Sixma JJ, Gros P, Science. 2002 Aug 16;297(5584):1176-9. PMID:12183630
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