1mp8
From Proteopedia
(New page: 200px<br /> <applet load="1mp8" size="450" color="white" frame="true" align="right" spinBox="true" caption="1mp8, resolution 1.60Å" /> '''Crystal structure o...) |
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caption="1mp8, resolution 1.60Å" /> | caption="1mp8, resolution 1.60Å" /> | ||
'''Crystal structure of Focal Adhesion Kinase (FAK)'''<br /> | '''Crystal structure of Focal Adhesion Kinase (FAK)'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1MP8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ADP as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] Full crystallographic information is available from [http:// | + | 1MP8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ADP:'>ADP</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MP8 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: tyrosine protein kinase]] | [[Category: tyrosine protein kinase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:25:04 2008'' |
Revision as of 14:25, 15 February 2008
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Crystal structure of Focal Adhesion Kinase (FAK)
Overview
Protein kinases are important drug targets in human cancers, inflammation, and metabolic diseases. This report presents the structures of kinase, domains for three cancer-associated protein kinases: ephrin receptor A2, (EphA2), focal adhesion kinase (FAK), and Aurora-A. The expression, profiles of EphA2, FAK, and Aurora-A in carcinomas suggest that inhibitors, of these kinases may have inherent potential as therapeutic agents. The, structures were determined from crystals grown in nanovolume droplets, which produced high-resolution diffraction data at 1.7, 1.9, and 2.3 A for, FAK, Aurora-A, and EphA2, respectively. The FAK and Aurora-A structures, are the first determined within two unique subfamilies of human kinases, and all three structures provide new insights into kinase regulation and, the design of selective inhibitors.
About this Structure
1MP8 is a Single protein structure of sequence from Homo sapiens with as ligand. Active as Transferase, with EC number and 2.7.10.2 2.7.10.1 and 2.7.10.2 Full crystallographic information is available from OCA.
Reference
Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography., Nowakowski J, Cronin CN, McRee DE, Knuth MW, Nelson CG, Pavletich NP, Rogers J, Sang BC, Scheibe DN, Swanson RV, Thompson DA, Structure. 2002 Dec;10(12):1659-67. PMID:12467573
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