1n3h
From Proteopedia
(New page: 200px<br /> <applet load="1n3h" size="450" color="white" frame="true" align="right" spinBox="true" caption="1n3h" /> '''Coupling of Folding and Binding in the PTB ...) |
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'''Coupling of Folding and Binding in the PTB Domain of the Signaling Protein Shc'''<br /> | '''Coupling of Folding and Binding in the PTB Domain of the Signaling Protein Shc'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1N3H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1N3H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N3H OCA]. |
==Reference== | ==Reference== | ||
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[[Category: free protein]] | [[Category: free protein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:26:51 2008'' |
Revision as of 14:26, 15 February 2008
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Coupling of Folding and Binding in the PTB Domain of the Signaling Protein Shc
Overview
The notion that certain proteins lack intrinsic globular structure under, physiological conditions and that the attainment of fully folded structure, only occurs upon the binding of target molecules has been recently gaining, popularity. We report here the solution structure of the PTB domain of the, signaling protein Shc in the free form. Comparison of this structure with, that of the complex form, obtained previously with a phosphopeptide, ligand, reveals that the Shc PTB domain is structurally disordered in the, free form, particularly around the regions constituting the peptide, binding pocket. The binding of the ligand appears to reorganize this, pocket through local folding events triggering a conformational switch, between the free and the complex forms.
About this Structure
1N3H is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Coupling of folding and binding in the PTB domain of the signaling protein Shc., Farooq A, Zeng L, Yan KS, Ravichandran KS, Zhou MM, Structure. 2003 Aug;11(8):905-13. PMID:12906822
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