1nd7
From Proteopedia
(New page: 200px<br /> <applet load="1nd7" size="450" color="white" frame="true" align="right" spinBox="true" caption="1nd7, resolution 2.1Å" /> '''Conformational Flexi...) |
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caption="1nd7, resolution 2.1Å" /> | caption="1nd7, resolution 2.1Å" /> | ||
'''Conformational Flexibility Underlies Ubiquitin Ligation Mediated by the WWP1 HECT domain E3 Ligase'''<br /> | '''Conformational Flexibility Underlies Ubiquitin Ligation Mediated by the WWP1 HECT domain E3 Ligase'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1ND7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1ND7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ND7 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: wwp1]] | [[Category: wwp1]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:28:32 2008'' |
Revision as of 14:28, 15 February 2008
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Conformational Flexibility Underlies Ubiquitin Ligation Mediated by the WWP1 HECT domain E3 Ligase
Overview
Ubiquitin ligases (E3) select proteins for ubiquitylation, a modification, that directs altered subcellular trafficking and/or degradation of the, target protein. HECT domain E3 ligases not only recognize, but also, directly catalyze, ligation of ubiquitin to their protein substrates. The, crystal structure of the HECT domain of the human ubiquitin ligase, WWP1/AIP5 maintains a two-lobed structure like the HECT domain of the, human ubiquitin ligase E6AP. While the individual N and C lobes of WWP1, possess very similar folds to those of E6AP, the organization of the two, lobes relative to one another is different from E6AP due to a rotation, about a polypeptide hinge linking the N and C lobes. Mutational analyses, suggest that a range of conformations achieved by rotation about this, hinge region is essential for catalytic activity.
About this Structure
1ND7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase., Verdecia MA, Joazeiro CA, Wells NJ, Ferrer JL, Bowman ME, Hunter T, Noel JP, Mol Cell. 2003 Jan;11(1):249-59. PMID:12535537
Page seeded by OCA on Fri Feb 15 16:28:32 2008
Categories: Homo sapiens | Single protein | Bowman, M.E. | Ferrer, J.L. | Hunter, T. | Joaziero, C.A.P. | Noel, J.P. | Verdecia, M.A. | Wells, N.J. | E3 | Hect | Ligase | Ubiquitin | Wwp1
