User:Marvin O'Neal/OspC
From Proteopedia
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| - | <Structure load='1GGQ' size='500' frame='true' align='right' caption=' | + | <Structure load='1GGQ' size='500' frame='true' align='right' caption='OspC B31 (1GGQ)' scene='OspC B31 (1GGQ)' /> |
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Revision as of 19:18, 26 April 2012
Hello!
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This is the which we came out after reading the primary literature.
Contents |
Introduction
Lyme disease is a typical epidemic in northeastern region. The patients begin with skin lesions which later develop into more severe neurological and cardiac symptoms. Human Lyme disease is the most prevalent tick-borne disease which is caused by Borrelia burgdoferi,a spirochete that is identified in Ixodes scapulars. The outer surface protein C (ospC) on Borrelia burgdoferi is induced when the tick migrates from guts to salivary gland during feeding period. OspC is diversed that it is categorized into 19 outer surface protein major groups (OMGs). Only four invasive allelic groups, A, B, I, and K, are responsible for causing human Lyme disease.
Ecology of Lyme Disease
Ecological factors responsible for Human Lyme disease rates
Dilution Effect Model
Outer Surface Protein (OspC)
OpC usually exists as a dimer with dominant structures of and 2 β-sheets. The model of OMG A, which is known as strain B31, is used to emphasize the polymorphism and pathogenesis of ospC. Since random coil is the most antigenic site on the protein, pink and red colors were applied to protein in order to differentiate the polymorphism among these major antigenic sites (Earnhart 2010).
