Reserved Sandbox 452
From Proteopedia
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== Introduction == | == Introduction == | ||
| - | C-Myc is a [http://en.wikipedia.org/wiki/Transcription_factor transcription factor] involved in the [http://en.wikipedia.org/wiki/Cell_cycle cell cycle] specifically with the stimulation of cell proliferation but is also involved in the regulation of [http://en.wikipedia.org/wiki/Apoptosis apoptosis], [http://en.wikipedia.org/wiki/Cell_differentiation cell differentiation], cell competition, and [http://en.wikipedia.org/wiki/Senescence senescence] <ref>PMID:22510570</ref>. C-Myc is a [http://en.wikipedia.org/wiki/DNA-binding_proteinDNA binding protein] and functions primarily by inducing transcription through the formation of | + | C-Myc is a [http://en.wikipedia.org/wiki/Transcription_factor transcription factor] involved in the [http://en.wikipedia.org/wiki/Cell_cycle cell cycle] specifically with the stimulation of cell proliferation but is also involved in the regulation of [http://en.wikipedia.org/wiki/Apoptosis apoptosis], [http://en.wikipedia.org/wiki/Cell_differentiation cell differentiation], cell competition, and [http://en.wikipedia.org/wiki/Senescence senescence] <ref>PMID:22510570</ref>. C-Myc is a [http://en.wikipedia.org/wiki/DNA-binding_proteinDNA binding protein] and functions primarily by inducing transcription through the formation of [http://en.wikipedia.org/wiki/Protein_dimerheterodimers] primarily with [http://en.wikipedia.org/wiki/MAX_(gene)Max proteins]. C-Myc's interactions are not limited to only Max protiens as it has been shown to interact with [http://en.wikipedia.org/wiki/BRCA1BRCA1], [http://en.wikipedia.org/wiki/Mapk1MAPK1], [http://en.wikipedia.org/wiki/P73p73], and many more. |
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== Structure == | == Structure == | ||
| - | The c-myc protein contains two specific regions that characterize them as transcription factors: a carboxy-terminal basix helix-loop-helix leucine zipper motif and an amino terminal transactivation domain<ref>PMID:8193530</ref>. | + | The c-myc protein contains two specific regions that characterize them as transcription factors: a carboxy-terminal basix helix-loop-helix leucine zipper motif and an amino terminal transactivation domain<ref>PMID:8193530</ref>. Immediatley following the basic region within the c-myc protein is the helix -loop-helix motif which has been shown to interact with DNA through binding <ref>PMID:8193530</ref> |
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| + | == Medical Uses and Therapeutic Opportunities == | ||
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Revision as of 23:49, 26 April 2012
Contents |
C-Myc
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Introduction
C-Myc is a transcription factor involved in the cell cycle specifically with the stimulation of cell proliferation but is also involved in the regulation of apoptosis, cell differentiation, cell competition, and senescence [1]. C-Myc is a binding protein and functions primarily by inducing transcription through the formation of [1] primarily with proteins. C-Myc's interactions are not limited to only Max protiens as it has been shown to interact with [2], [3], [4], and many more.
Structure
The c-myc protein contains two specific regions that characterize them as transcription factors: a carboxy-terminal basix helix-loop-helix leucine zipper motif and an amino terminal transactivation domain[2]. Immediatley following the basic region within the c-myc protein is the helix -loop-helix motif which has been shown to interact with DNA through binding [3]
Medical Uses and Therapeutic Opportunities
References
- ↑ Uribesalgo I, Benitah SA, Di Croce L. From oncogene to tumor suppressor: The dual role of Myc in leukemia. Cell Cycle. 2012 May 1;11(9). PMID:22510570
- ↑ Amati B, Land H. Myc-Max-Mad: a transcription factor network controlling cell cycle progression, differentiation and death. Curr Opin Genet Dev. 1994 Feb;4(1):102-8. PMID:8193530
- ↑ Amati B, Land H. Myc-Max-Mad: a transcription factor network controlling cell cycle progression, differentiation and death. Curr Opin Genet Dev. 1994 Feb;4(1):102-8. PMID:8193530
