Reserved Sandbox 452

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 8: Line 8:
== Introduction ==
== Introduction ==
-
C-Myc is a [http://en.wikipedia.org/wiki/Transcription_factor transcription factor] involved in the [http://en.wikipedia.org/wiki/Cell_cycle cell cycle] specifically with the stimulation of cell proliferation but is also involved in the regulation of [http://en.wikipedia.org/wiki/Apoptosis apoptosis], [http://en.wikipedia.org/wiki/Cell_differentiation cell differentiation], cell competition, and [http://en.wikipedia.org/wiki/Senescence senescence] <ref>PMID:22510570</ref>. C-Myc is a [http://en.wikipedia.org/wiki/DNA-binding_proteinDNA binding protein] and functions primarily by inducing transcription through the formation of [http://en.wikipedia.org/wiki/Protein_dimerheterodimers] primarily with [http://en.wikipedia.org/wiki/MAX_(gene)Max proteins]. C-Myc's interactions are not limited to only Max protiens as it has been shown to interact with [http://en.wikipedia.org/wiki/BRCA1BRCA1], [http://en.wikipedia.org/wiki/Mapk1MAPK1], [http://en.wikipedia.org/wiki/P73p73], and many more.
+
C-Myc is a [http://en.wikipedia.org/wiki/Transcription_factor transcription factor] involved in the [http://en.wikipedia.org/wiki/Cell_cycle cell cycle] specifically with the stimulation of cell proliferation but is also involved in the regulation of [http://en.wikipedia.org/wiki/Apoptosis apoptosis], [http://en.wikipedia.org/wiki/Cell_differentiation cell differentiation], cell competition, and [http://en.wikipedia.org/wiki/Senescence senescence] <ref>PMID:22510570</ref>. C-Myc is a [http://en.wikipedia.org/wiki/DNA-binding_proteinDNA binding protein] and functions primarily by inducing transcription through the formation of [http://en.wikipedia.org/wiki/Protein_dimerheterodimers] primarily with [http://en.wikipedia.org/wiki/MAX_(gene) Max proteins]. C-Myc's interactions are not limited to only Max protiens as it has been shown to interact with [http://en.wikipedia.org/wiki/BRCA1 BRCA1], [http://en.wikipedia.org/wiki/Mapk1 MAPK1], [http://en.wikipedia.org/wiki/P73 p73], and many more.

Revision as of 23:52, 26 April 2012

Contents

C-Myc

Insert caption here

Drag the structure with the mouse to rotate

Template:STRUCTURE 1A93


-->

Introduction

C-Myc is a transcription factor involved in the cell cycle specifically with the stimulation of cell proliferation but is also involved in the regulation of apoptosis, cell differentiation, cell competition, and senescence [1]. C-Myc is a binding protein and functions primarily by inducing transcription through the formation of [1] primarily with Max proteins. C-Myc's interactions are not limited to only Max protiens as it has been shown to interact with BRCA1, MAPK1, p73, and many more.



Structure

The c-myc protein contains two specific regions that characterize them as transcription factors: a carboxy-terminal basix helix-loop-helix leucine zipper motif and an amino terminal transactivation domain[2]. Immediatley following the basic region within the c-myc protein is the helix -loop-helix motif which has been shown to interact with DNA through binding [3]


Medical Uses and Therapeutic Opportunities

References

  1. ↑ Uribesalgo I, Benitah SA, Di Croce L. From oncogene to tumor suppressor: The dual role of Myc in leukemia. Cell Cycle. 2012 May 1;11(9). PMID:22510570
  2. ↑ Amati B, Land H. Myc-Max-Mad: a transcription factor network controlling cell cycle progression, differentiation and death. Curr Opin Genet Dev. 1994 Feb;4(1):102-8. PMID:8193530
  3. ↑ Amati B, Land H. Myc-Max-Mad: a transcription factor network controlling cell cycle progression, differentiation and death. Curr Opin Genet Dev. 1994 Feb;4(1):102-8. PMID:8193530

Proteopedia Page Contributors and Editors (what is this?)

Megan R. Askew

Retrieved from "http://52.214.119.220/wiki/index.php/Reserved_Sandbox_452"
Personal tools