1nte
From Proteopedia
(New page: 200px<br /> <applet load="1nte" size="450" color="white" frame="true" align="right" spinBox="true" caption="1nte, resolution 1.24Å" /> '''CRYSTAL STRUCTURE A...) |
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caption="1nte, resolution 1.24Å" /> | caption="1nte, resolution 1.24Å" /> | ||
'''CRYSTAL STRUCTURE ANALYSIS OF THE SECOND PDZ DOMAIN OF SYNTENIN'''<br /> | '''CRYSTAL STRUCTURE ANALYSIS OF THE SECOND PDZ DOMAIN OF SYNTENIN'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1NTE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with O as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1NTE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=O:'>O</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NTE OCA]. |
==Reference== | ==Reference== | ||
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[[Category: syntenin]] | [[Category: syntenin]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:30:45 2008'' |
Revision as of 14:30, 15 February 2008
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CRYSTAL STRUCTURE ANALYSIS OF THE SECOND PDZ DOMAIN OF SYNTENIN
Overview
Crystal structures of the PDZ2 domain of the scaffolding protein syntenin, both unbound and in complexes with peptides derived from C termini of IL5, receptor (alpha chain) and syndecan, reveal the molecular roots of, syntenin's degenerate specificity. Three distinct binding sites (S(0), S(-1), and S(-2)), with affinities for hydrophobic side chains, function, in a combinatorial way: S(-1) and S(-2) act together to bind syndecan, while S(0) and S(-1) are involved in the binding of IL5Ralpha. Neither, mode of interaction is consistent with the prior classification scheme, which defined the IL5Ralpha interaction as class I (-S/T-X-phi) and the, syndecan interaction as class II (-phi-X-phi). These results, in, conjunction with other emerging structural data on PDZ domains, call for a, revision of their classification and of the existing model of their, mechanism.
About this Structure
1NTE is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Molecular roots of degenerate specificity in syntenin's PDZ2 domain: reassessment of the PDZ recognition paradigm., Kang BS, Cooper DR, Devedjiev Y, Derewenda U, Derewenda ZS, Structure. 2003 Jul;11(7):845-53. PMID:12842047
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