1nzq
From Proteopedia
(New page: 200px<br /> <applet load="1nzq" size="450" color="white" frame="true" align="right" spinBox="true" caption="1nzq, resolution 2.18Å" /> '''D-Phe-Pro-Arg-Type ...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1nzq. | + | [[Image:1nzq.jpg|left|200px]]<br /><applet load="1nzq" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1nzq" size=" | + | |
caption="1nzq, resolution 2.18Å" /> | caption="1nzq, resolution 2.18Å" /> | ||
'''D-Phe-Pro-Arg-Type Thrombin Inhibitor'''<br /> | '''D-Phe-Pro-Arg-Type Thrombin Inhibitor'''<br /> | ||
| Line 11: | Line 10: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1NZQ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with 162 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] Full crystallographic information is available from [http:// | + | 1NZQ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=162:'>162</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NZQ OCA]. |
==Reference== | ==Reference== | ||
| Line 28: | Line 27: | ||
[[Category: thrombin inhibitor]] | [[Category: thrombin inhibitor]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:31:41 2008'' |
Revision as of 14:31, 15 February 2008
|
D-Phe-Pro-Arg-Type Thrombin Inhibitor
Contents |
Overview
Synthesis of thrombin inhibitors and their binding mode to thrombin is, described. Modification of the P1 moiety leads to an increased selectivity, versus trypsin. The observed selectivity is discussed in view of their, thrombin-inhibitor complex X-ray structures.
Disease
Known diseases associated with this structure: Dysprothrombinemia OMIM:[176930], Hyperprothrombinemia OMIM:[176930], Hypoprothrombinemia OMIM:[176930]
About this Structure
1NZQ is a Protein complex structure of sequences from Homo sapiens with as ligand. Active as Thrombin, with EC number 3.4.21.5 Full crystallographic information is available from OCA.
Reference
D-Phe-Pro-Arg type thrombin inhibitors: unexpected selectivity by modification of the P1 moiety., Lange UE, Baucke D, Hornberger W, Mack H, Seitz W, Hoffken HW, Bioorg Med Chem Lett. 2003 Jun 16;13(12):2029-33. PMID:12781189
Page seeded by OCA on Fri Feb 15 16:31:41 2008
