1o0d
From Proteopedia
(New page: 200px<br /> <applet load="1o0d" size="450" color="white" frame="true" align="right" spinBox="true" caption="1o0d, resolution 2.44Å" /> '''Human Thrombin comp...) |
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caption="1o0d, resolution 2.44Å" /> | caption="1o0d, resolution 2.44Å" /> | ||
'''Human Thrombin complexed with a d-Phe-Pro-Arg-type Inhibitor and a C-terminal Hirudin derived exo-site inhibitor'''<br /> | '''Human Thrombin complexed with a d-Phe-Pro-Arg-type Inhibitor and a C-terminal Hirudin derived exo-site inhibitor'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1O0D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with 163 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] Full crystallographic information is available from [http:// | + | 1O0D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=163:'>163</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O0D OCA]. |
==Reference== | ==Reference== | ||
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[[Category: ternary complex; thrombin/active-site inhibitor/exo-site inhibitor]] | [[Category: ternary complex; thrombin/active-site inhibitor/exo-site inhibitor]] | ||
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Revision as of 14:31, 15 February 2008
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Human Thrombin complexed with a d-Phe-Pro-Arg-type Inhibitor and a C-terminal Hirudin derived exo-site inhibitor
Contents |
Overview
Synthesis of thrombin inhibitors and their binding mode to thrombin is, described. Modification of the P1 moiety leads to an increased selectivity, versus trypsin. The observed selectivity is discussed in view of their, thrombin-inhibitor complex X-ray structures.
Disease
Known diseases associated with this structure: Dysprothrombinemia OMIM:[176930], Hyperprothrombinemia OMIM:[176930], Hypoprothrombinemia OMIM:[176930]
About this Structure
1O0D is a Protein complex structure of sequences from Homo sapiens with as ligand. Active as Thrombin, with EC number 3.4.21.5 Full crystallographic information is available from OCA.
Reference
D-Phe-Pro-Arg type thrombin inhibitors: unexpected selectivity by modification of the P1 moiety., Lange UE, Baucke D, Hornberger W, Mack H, Seitz W, Hoffken HW, Bioorg Med Chem Lett. 2003 Jun 16;13(12):2029-33. PMID:12781189
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